Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors

Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors

© 2015 Elsevier Ltd. Abstract A series of 1,4-disubstituted-1,2,3-triazoles (13-35) containing sulfonamide moiety were synthesized and evaluated for their aromatase inhibitory effects. Most triazoles with open-chain sulfonamide showed significant aromatase inhibitory activity (IC50= 1.3-9.4 μM). Int...

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Main Authors: Ratchanok Pingaew, Veda Prachayasittikul, Prasit Mandi, Chanin Nantasenamat, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Other Authors: Srinakharinwirot University
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/35617
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/35617

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