Human norovirus genogroup II recombinants in Thailand, 2009–2014

Human norovirus genogroup II recombinants in Thailand, 2009–2014

© 2015, Springer-Verlag Wien. Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis worldwide. New strains emerge partly due to viral recombination. In Thailand, there is a lack of data on NoV recombinants among clinical isolates. We screened stool samples from pediatric diarrheal p...

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Main Authors: Tikumporn Phumpholsup, Thaweesak Chieochansin, Sompong Vongpunsawad, Viboonsuk Vuthitanachot, Sunchai Payungporn, Yong Poovorawan
Other Authors: Chulalongkorn University
Format: Article
Published: 2018
Subjects:
Immunology and Microbiology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/36057
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spelling th-mahidol.360572018-11-23T17:14:37Z Human norovirus genogroup II recombinants in Thailand, 2009–2014 Tikumporn Phumpholsup Thaweesak Chieochansin Sompong Vongpunsawad Viboonsuk Vuthitanachot Sunchai Payungporn Yong Poovorawan Chulalongkorn University Mahidol University Chum Phae Hospital Immunology and Microbiology © 2015, Springer-Verlag Wien. Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis worldwide. New strains emerge partly due to viral recombination. In Thailand, there is a lack of data on NoV recombinants among clinical isolates. We screened stool samples from pediatric diarrheal patients for norovirus by RT-PCR and found GII.4 to be the most prevalent genotype. Phylogenetic and SimPlot analyses detected seven intra-genogroup recombinant strains: three GII.21/GII.3, two GII.12/GII.3, and two GII.12/GII.1 recombinants. Maximum chi-square analysis indicated that all had similar breakpoints near the ORF1/ORF2 junction (p < 0.001), either slightly upstream within the C-terminus of RdRp or downstream within the N-terminal domain of VP1. 2018-11-23T10:14:37Z 2018-11-23T10:14:37Z 2015-10-30 Article Archives of Virology. Vol.160, No.10 (2015), 2603-2609 10.1007/s00705-015-2545-5 03048608 2-s2.0-84942502923 https://repository.li.mahidol.ac.th/handle/123456789/36057 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942502923&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Immunology and Microbiology
spellingShingle Immunology and Microbiology
Tikumporn Phumpholsup
Thaweesak Chieochansin
Sompong Vongpunsawad
Viboonsuk Vuthitanachot
Sunchai Payungporn
Yong Poovorawan
Human norovirus genogroup II recombinants in Thailand, 2009–2014
description © 2015, Springer-Verlag Wien. Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis worldwide. New strains emerge partly due to viral recombination. In Thailand, there is a lack of data on NoV recombinants among clinical isolates. We screened stool samples from pediatric diarrheal patients for norovirus by RT-PCR and found GII.4 to be the most prevalent genotype. Phylogenetic and SimPlot analyses detected seven intra-genogroup recombinant strains: three GII.21/GII.3, two GII.12/GII.3, and two GII.12/GII.1 recombinants. Maximum chi-square analysis indicated that all had similar breakpoints near the ORF1/ORF2 junction (p < 0.001), either slightly upstream within the C-terminus of RdRp or downstream within the N-terminal domain of VP1.
author2 Chulalongkorn University
author_facet Chulalongkorn University
Tikumporn Phumpholsup
Thaweesak Chieochansin
Sompong Vongpunsawad
Viboonsuk Vuthitanachot
Sunchai Payungporn
Yong Poovorawan
format Article
author Tikumporn Phumpholsup
Thaweesak Chieochansin
Sompong Vongpunsawad
Viboonsuk Vuthitanachot
Sunchai Payungporn
Yong Poovorawan
author_sort Tikumporn Phumpholsup
title Human norovirus genogroup II recombinants in Thailand, 2009–2014
title_short Human norovirus genogroup II recombinants in Thailand, 2009–2014
title_full Human norovirus genogroup II recombinants in Thailand, 2009–2014
title_fullStr Human norovirus genogroup II recombinants in Thailand, 2009–2014
title_full_unstemmed Human norovirus genogroup II recombinants in Thailand, 2009–2014
title_sort human norovirus genogroup ii recombinants in thailand, 2009–2014
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/36057
_version_ 1763495675577761792

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