Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand

Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand

Copyright © 2015, American Society for Microbiology. All Rights Reserved. Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two pop...

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Main Authors: Tiphaine Gaillard, Kanlaya Sriprawat, Sébastien Briolant, Chirapat Wangsing, Nathalie Wurtz, Meïli Baragatti, Morgane Lavina, Aurélie Pascual, François Nosten, Bruno Pradines
Other Authors: Institut de recherche biomedicale des armees
Format: Article
Published: 2018
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/36370
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spelling th-mahidol.363702018-11-23T17:40:11Z Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand Tiphaine Gaillard Kanlaya Sriprawat Sébastien Briolant Chirapat Wangsing Nathalie Wurtz Meïli Baragatti Morgane Lavina Aurélie Pascual François Nosten Bruno Pradines Institut de recherche biomedicale des armees Unite de Recherche sur les Maladies Infectieuses et Tropicales emergentes HIA Sainte-Anne a Toulon Mahidol University Direction Inter-Armées du Service de Santé Institut Pasteur de la Guyane Mathematiques informatiques et statistique pour l’environnement et l’agronomie (MISTEA) Centre National de Référence du Paludisme University of Oxford Medicine Copyright © 2015, American Society for Microbiology. All Rights Reserved. Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between the group with low IC50s versus the group with high IC50s with regard to copy numbers of the Plasmodium falciparum tetQ (pftetQ) gene (P = 0.11) or pfmdt gene (P = 0.87) or the number of PfTetQ KYNNNN repeats (P = 0.72). 2018-11-23T10:40:11Z 2018-11-23T10:40:11Z 2015-08-01 Article Antimicrobial Agents and Chemotherapy. Vol.59, No.8 (2015), 5080-5083 10.1128/AAC.00345-15 10986596 00664804 2-s2.0-84939825761 https://repository.li.mahidol.ac.th/handle/123456789/36370 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939825761&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Tiphaine Gaillard
Kanlaya Sriprawat
Sébastien Briolant
Chirapat Wangsing
Nathalie Wurtz
Meïli Baragatti
Morgane Lavina
Aurélie Pascual
François Nosten
Bruno Pradines
Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
description Copyright © 2015, American Society for Microbiology. All Rights Reserved. Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between the group with low IC50s versus the group with high IC50s with regard to copy numbers of the Plasmodium falciparum tetQ (pftetQ) gene (P = 0.11) or pfmdt gene (P = 0.87) or the number of PfTetQ KYNNNN repeats (P = 0.72).
author2 Institut de recherche biomedicale des armees
author_facet Institut de recherche biomedicale des armees
Tiphaine Gaillard
Kanlaya Sriprawat
Sébastien Briolant
Chirapat Wangsing
Nathalie Wurtz
Meïli Baragatti
Morgane Lavina
Aurélie Pascual
François Nosten
Bruno Pradines
format Article
author Tiphaine Gaillard
Kanlaya Sriprawat
Sébastien Briolant
Chirapat Wangsing
Nathalie Wurtz
Meïli Baragatti
Morgane Lavina
Aurélie Pascual
François Nosten
Bruno Pradines
author_sort Tiphaine Gaillard
title Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
title_short Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
title_full Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
title_fullStr Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
title_full_unstemmed Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
title_sort molecular markers and in vitro susceptibility to doxycycline in plasmodium falciparum isolates from thailand
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/36370
_version_ 1763494781545086976

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