Pharmacokinetic interactions between primaquine and pyronaridine-artesunate in healthy adult Thai subjects

• Main Authors: Podjanee Jittamala, Sasithon Pukrittayakamee, Elizabeth A. Ashley, François Nosten, Borimas Hanboonkunupakarn, Sue J. Lee, Praiya Thana, Kalayanee Chairat, Daniel Blessborn, Salwaluk Panapipat, Nicholas J. White, Nicholas P.J. Day, Joel Tarningb
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/36863

© 2015 Jittamala et al. Pyronaridine-artesunate is a newly introduced artemisinin-based combination treatment which may be deployed together with primaquine. A single-dose, randomized, three-sequence crossover study was conducted in healthy Thai volunteers to characterize potential pharmacokinetic i...