High efficacy of primaquine treatment for plasmodium vivax in western Thailand
© 2016 by The American Society of Tropical Medicine and Hygiene. Primaquine is the only licensed antimalarial drug that is capable of clearing dormant Plasmodium vivax liver stage parasites. To date, there is no clear evidence of resistance of the liver stage parasite against this drug, because of t...
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th-mahidol.407162019-03-14T15:01:36Z High efficacy of primaquine treatment for plasmodium vivax in western Thailand Rhea J. Longley Piyarat Sripoorote Pornpimol Chobson Teerawat Saeseu Chonlaphat Sukasem Suparat Phuanukoonnon Wang Nguitragool Ivo Mueller Jetsumon Sattabongkot Mahidol University Walter and Eliza Hall Institute of Medical Research University of Melbourne Instituto de Salud Global de Barcelona Immunology and Microbiology Medicine © 2016 by The American Society of Tropical Medicine and Hygiene. Primaquine is the only licensed antimalarial drug that is capable of clearing dormant Plasmodium vivax liver stage parasites. To date, there is no clear evidence of resistance of the liver stage parasite against this drug, because of the difficulty in ascertaining the cause of recurrent infection. We followed 52 Thai P. vivax patients for 9 months after directly observed treatment of 15 mg primaquine daily for 14 days. Blood samples taken at 2-4 weekly intervals were assessed by microscopy and polymerase chain reaction (PCR) for the presence of parasites. Only four of 52 (7.7%) volunteers had recurrent P. vivax infections, all at least 8 weeks after treatment. This demonstrates that primaquine retains a high efficacy in this population. Although a risk of new infections could not be ruled out, parasite genotyping at two polymorphic markers suggested a high probability of late relapsing infections in these volunteers. Continued monitoring of primaquine efficacy in this region is advisable. 2018-12-11T02:57:09Z 2019-03-14T08:01:36Z 2018-12-11T02:57:09Z 2019-03-14T08:01:36Z 2016-11-01 Article American Journal of Tropical Medicine and Hygiene. Vol.95, No.5 (2016), 1086-1089 10.4269/ajtmh.16-0410 00029637 2-s2.0-84994298836 https://repository.li.mahidol.ac.th/handle/123456789/40716 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84994298836&origin=inward |
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Immunology and Microbiology Medicine Rhea J. Longley Piyarat Sripoorote Pornpimol Chobson Teerawat Saeseu Chonlaphat Sukasem Suparat Phuanukoonnon Wang Nguitragool Ivo Mueller Jetsumon Sattabongkot High efficacy of primaquine treatment for plasmodium vivax in western Thailand |
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© 2016 by The American Society of Tropical Medicine and Hygiene. Primaquine is the only licensed antimalarial drug that is capable of clearing dormant Plasmodium vivax liver stage parasites. To date, there is no clear evidence of resistance of the liver stage parasite against this drug, because of the difficulty in ascertaining the cause of recurrent infection. We followed 52 Thai P. vivax patients for 9 months after directly observed treatment of 15 mg primaquine daily for 14 days. Blood samples taken at 2-4 weekly intervals were assessed by microscopy and polymerase chain reaction (PCR) for the presence of parasites. Only four of 52 (7.7%) volunteers had recurrent P. vivax infections, all at least 8 weeks after treatment. This demonstrates that primaquine retains a high efficacy in this population. Although a risk of new infections could not be ruled out, parasite genotyping at two polymorphic markers suggested a high probability of late relapsing infections in these volunteers. Continued monitoring of primaquine efficacy in this region is advisable. |
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Mahidol University |
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Mahidol University Rhea J. Longley Piyarat Sripoorote Pornpimol Chobson Teerawat Saeseu Chonlaphat Sukasem Suparat Phuanukoonnon Wang Nguitragool Ivo Mueller Jetsumon Sattabongkot |
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Article |
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Rhea J. Longley Piyarat Sripoorote Pornpimol Chobson Teerawat Saeseu Chonlaphat Sukasem Suparat Phuanukoonnon Wang Nguitragool Ivo Mueller Jetsumon Sattabongkot |
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Rhea J. Longley |
title |
High efficacy of primaquine treatment for plasmodium vivax in western Thailand |
title_short |
High efficacy of primaquine treatment for plasmodium vivax in western Thailand |
title_full |
High efficacy of primaquine treatment for plasmodium vivax in western Thailand |
title_fullStr |
High efficacy of primaquine treatment for plasmodium vivax in western Thailand |
title_full_unstemmed |
High efficacy of primaquine treatment for plasmodium vivax in western Thailand |
title_sort |
high efficacy of primaquine treatment for plasmodium vivax in western thailand |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/40716 |
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1763489100086640640 |