Optimal design strategies for relative potency using the two-parameter log-logistic model
© 2016 - IOS Press and the authors. All rights reserved. In this paper, we focus on the D- and Ds-optimal designs for two-parameter log-logistic (LL2) relative potency model where the response variables are normal and binomial distributions. The D- and Ds-optimal designs are obtained by using D-opti...
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/40935 |
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| Institution: | Mahidol University |
| Summary: | © 2016 - IOS Press and the authors. All rights reserved. In this paper, we focus on the D- and Ds-optimal designs for two-parameter log-logistic (LL2) relative potency model where the response variables are normal and binomial distributions. The D- and Ds-optimal designs are obtained by using D-optimal design and nesting strategy criterions, respectively. Furthermore, the general equivalence theorems is used to guarantee the D- and Ds-optimal designs. The results show that we obtain four support points for D-optimal designs and two support points for Ds-optimal designs. |
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