Antimalarial activity of KAF156 in falciparum and vivax malaria

• Main Authors: Nicholas J. White, Tran T. Duong, Chirapong Uthaisin, Fran'ois Nosten, Aung P. Phyo, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Podjanee Jittamala, Kittiphum Chuthasmit, Ming S. Cheung, Yiyan Feng, Ruobing Li, Baldur Magnusson, Marc Sultan, Daniela Wieser, Xiaolei Xun, Rong Zhao, Thierry T. Diagana, Peter Pertel, F. Joel Leong
• Other Authors: Mahidol-Oxford Tropical Medicine Research Unit
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/41132
• Institution: Mahidol University

© 2016 Massachusetts Medical Society. All rights reserved. Background KAF156 belongs to a new class of antimalarial agents (imidazolopiperazines), with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. METHODS We conducted a phase 2, open-la...