MIR-34 MIRNAs regulate cellular senescence in type II alveolar epithelial cells of patients with idiopathic pulmonary fibrosis

• Main Authors: Supparerk Disayabutr, Eun Kyung Kim, Seung Ick Cha, Gary Green, Ram P. Naikawadi, Kirk D. Jones, Jeffrey A. Golden, Aaron Schroeder, Michael A. Matthay, Jasleen Kukreja, David J. Erle, Harold R. Collard, Paul J. Wolters
• Other Authors: University of California, San Francisco
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/41470
• Institution: Mahidol University

Pathologic features of idiopathic pulmonary fibrosis (IPF) include genetic predisposition, activation of the unfolded protein response, telomere attrition, and cellular senescence. The mechanisms leading to alveolar epithelial cell (AEC) senescence are poorly understood. MicroRNAs (miRNAs) have been...