Transcriptional memory of cells of origin overrides β-catenin requirement of MLL cancer stem cells

• Main Authors: Teerapong Siriboonpiputtana, Bernd B. Zeisig, Magdalena Zarowiecki, Tsz Kan Fung, Maria Mallardo, Chiou Tsun Tsai, Priscilla Nga Ieng Lau, Quoc Chinh Hoang, Pedro Veiga, Jo Barnes, Claire Lynn, Amanda Wilson, Boris Lenhard, Chi Wai Eric So
• Other Authors: King's College London
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/41678
• Institution: Mahidol University

© 2017 The Authors While β-catenin has been demonstrated as an essential molecule and therapeutic target for various cancer stem cells (CSCs) including those driven by MLL fusions, here we show that transcriptional memory from cells of origin predicts AML patient survival and allows β-catenin-indepe...