The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to HPAI H5N1 infection
© 2017 Elsevier Inc. The interplay between highly pathogenic avian influenza (HPAI) H5N1 virus and immune cells has been extensively studied for years, as host immune components are thought to play significant roles in promoting the systemic spread of the virus and responsible for cytokine storm. Pr...
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th-mahidol.417802019-03-14T15:02:46Z The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to HPAI H5N1 infection Prasit Na-Ek Jutarat Thewsoongnoen Maytawan Thanunchai Suwimon Wiboon-Ut Noppadol Sa-Ard-Iam Rangsini Mahanonda Arunee Thitithanyanont Mahidol University Vajira Hospital Chulalongkorn University Biochemistry, Genetics and Molecular Biology © 2017 Elsevier Inc. The interplay between highly pathogenic avian influenza (HPAI) H5N1 virus and immune cells has been extensively studied for years, as host immune components are thought to play significant roles in promoting the systemic spread of the virus and responsible for cytokine storm. Previous studies suggested that the interaction of B cells and monocytes could promote HPAI H5N1 infection by enhancing avian influenza virus receptor expression. In this study, we further investigate the relationship between the HPAI H5N1 virus, activated B cells, and DC-SIGN expression. DC-SIGN has been described as an important factor for mediating various types of viral infection. Here, we first demonstrate that HPAI H5N1 infection could induce an activation of B cells, which was associated with DC-SIGN expression. Using CD40L and recombinant IL-4 for B cell stimulation, we determined that DC-SIGN expressed on activated B cells was able to enhance its susceptibility to HPAI H5N1 infection. Our findings uncover the interplay between this H5N1 virus and B cells and provide important information in understanding how the virus overcomes our immune system, contributing to its unusual immunopathogenesis. 2018-12-21T06:42:52Z 2019-03-14T08:02:46Z 2018-12-21T06:42:52Z 2019-03-14T08:02:46Z 2017-09-02 Article Biochemical and Biophysical Research Communications. Vol.490, No.4 (2017), 1301-1306 10.1016/j.bbrc.2017.07.017 10902104 0006291X 2-s2.0-85022040630 https://repository.li.mahidol.ac.th/handle/123456789/41780 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85022040630&origin=inward |
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Biochemistry, Genetics and Molecular Biology Prasit Na-Ek Jutarat Thewsoongnoen Maytawan Thanunchai Suwimon Wiboon-Ut Noppadol Sa-Ard-Iam Rangsini Mahanonda Arunee Thitithanyanont The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to HPAI H5N1 infection |
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© 2017 Elsevier Inc. The interplay between highly pathogenic avian influenza (HPAI) H5N1 virus and immune cells has been extensively studied for years, as host immune components are thought to play significant roles in promoting the systemic spread of the virus and responsible for cytokine storm. Previous studies suggested that the interaction of B cells and monocytes could promote HPAI H5N1 infection by enhancing avian influenza virus receptor expression. In this study, we further investigate the relationship between the HPAI H5N1 virus, activated B cells, and DC-SIGN expression. DC-SIGN has been described as an important factor for mediating various types of viral infection. Here, we first demonstrate that HPAI H5N1 infection could induce an activation of B cells, which was associated with DC-SIGN expression. Using CD40L and recombinant IL-4 for B cell stimulation, we determined that DC-SIGN expressed on activated B cells was able to enhance its susceptibility to HPAI H5N1 infection. Our findings uncover the interplay between this H5N1 virus and B cells and provide important information in understanding how the virus overcomes our immune system, contributing to its unusual immunopathogenesis. |
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Mahidol University |
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Mahidol University Prasit Na-Ek Jutarat Thewsoongnoen Maytawan Thanunchai Suwimon Wiboon-Ut Noppadol Sa-Ard-Iam Rangsini Mahanonda Arunee Thitithanyanont |
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Article |
author |
Prasit Na-Ek Jutarat Thewsoongnoen Maytawan Thanunchai Suwimon Wiboon-Ut Noppadol Sa-Ard-Iam Rangsini Mahanonda Arunee Thitithanyanont |
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Prasit Na-Ek |
title |
The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to HPAI H5N1 infection |
title_short |
The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to HPAI H5N1 infection |
title_full |
The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to HPAI H5N1 infection |
title_fullStr |
The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to HPAI H5N1 infection |
title_full_unstemmed |
The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to HPAI H5N1 infection |
title_sort |
activation of b cells enhances dc-sign expression and promotes susceptibility of b cells to hpai h5n1 infection |
publishDate |
2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/41780 |
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1763487449864994816 |