A convenient approach to facilitate monitoring Gaucher disease progression and therapeutic response

• Main Authors: Wujuan Zhang, Melissa Oehrle, Carlos E. Prada, Ida Vanessa D. Schwartz, Somchai Chutipongtanate, Duangrurdee Wattanasirichaigoon, Venette Inskeep, Mei Dai, Dao Pan, Ying Sun, Kenneth D.R. Setchell
• Other Authors: Cincinnati Children's Hospital Medical Center
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Environmental Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/41803
• Institution: Mahidol University

© 2017 The Royal Society of Chemistry. Gaucher disease (GD) is caused by mutations on the GBA1 gene leading to deficiency in acid β-glucosidase (GCase) and subsequent accumulation of its substrates, glucosylceramide (GlcC) and glucosylsphingosine (GlcS). GlcS in plasma has been proposed as a highly...