Insights into the naturally acquired immune response to Plasmodium vivax malaria
© Cambridge University Press 2016. Plasmodium vivax is the most geographically widespread of the malaria parasites causing human disease, yet it is comparatively understudied compared with Plasmodium falciparum. In this article we review what is known about naturally acquired immunity to P. Vivax, a...
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th-mahidol.418042019-03-14T15:02:48Z Insights into the naturally acquired immune response to Plasmodium vivax malaria Rhea J. Longley Jetsumon Sattabongkot Ivo Mueller Walter and Eliza Hall Institute of Medical Research Mahidol University University of Melbourne Instituto de Salud Global de Barcelona Agricultural and Biological Sciences Immunology and Microbiology © Cambridge University Press 2016. Plasmodium vivax is the most geographically widespread of the malaria parasites causing human disease, yet it is comparatively understudied compared with Plasmodium falciparum. In this article we review what is known about naturally acquired immunity to P. Vivax, and importantly, how this differs to that acquired against P. Falciparum. Immunity to clinical P. Vivax infection is acquired more quickly than to P. Falciparum, and evidence suggests humans in endemic areas also have a greater capacity to mount a successful immunological memory response to this pathogen. Both of these factors give promise to the idea of a successful P. Vivax vaccine. We review what is known about both the cellular and humoral immune response, including the role of cytokines, antibodies, immunoregulation, immune memory and immune dysfunction. Furthermore, we discuss where the future lies in terms of advancing our understanding of naturally acquired immunity to P. Vivax, through the use of well-designed longitudinal epidemiological studies and modern tools available to immunologists. 2018-12-11T02:02:14Z 2019-03-14T08:02:48Z 2018-12-11T02:02:14Z 2019-03-14T08:02:48Z 2016-02-01 Review Parasitology. Vol.143, No.2 (2016), 154-170 10.1017/S0031182015000670 14698161 00311820 2-s2.0-84958673928 https://repository.li.mahidol.ac.th/handle/123456789/41804 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84958673928&origin=inward |
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Agricultural and Biological Sciences Immunology and Microbiology Rhea J. Longley Jetsumon Sattabongkot Ivo Mueller Insights into the naturally acquired immune response to Plasmodium vivax malaria |
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© Cambridge University Press 2016. Plasmodium vivax is the most geographically widespread of the malaria parasites causing human disease, yet it is comparatively understudied compared with Plasmodium falciparum. In this article we review what is known about naturally acquired immunity to P. Vivax, and importantly, how this differs to that acquired against P. Falciparum. Immunity to clinical P. Vivax infection is acquired more quickly than to P. Falciparum, and evidence suggests humans in endemic areas also have a greater capacity to mount a successful immunological memory response to this pathogen. Both of these factors give promise to the idea of a successful P. Vivax vaccine. We review what is known about both the cellular and humoral immune response, including the role of cytokines, antibodies, immunoregulation, immune memory and immune dysfunction. Furthermore, we discuss where the future lies in terms of advancing our understanding of naturally acquired immunity to P. Vivax, through the use of well-designed longitudinal epidemiological studies and modern tools available to immunologists. |
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Walter and Eliza Hall Institute of Medical Research |
author_facet |
Walter and Eliza Hall Institute of Medical Research Rhea J. Longley Jetsumon Sattabongkot Ivo Mueller |
format |
Review |
author |
Rhea J. Longley Jetsumon Sattabongkot Ivo Mueller |
author_sort |
Rhea J. Longley |
title |
Insights into the naturally acquired immune response to Plasmodium vivax malaria |
title_short |
Insights into the naturally acquired immune response to Plasmodium vivax malaria |
title_full |
Insights into the naturally acquired immune response to Plasmodium vivax malaria |
title_fullStr |
Insights into the naturally acquired immune response to Plasmodium vivax malaria |
title_full_unstemmed |
Insights into the naturally acquired immune response to Plasmodium vivax malaria |
title_sort |
insights into the naturally acquired immune response to plasmodium vivax malaria |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/41804 |
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1763489523219562496 |