Modelling primaquine-induced haemolysis in G6PD deficiency

© Watson et al. Primaquine is the only drug available to prevent relapse in vivax malaria. The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd). As testing for G6PDd is often unav...

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Main Authors: James Watson, Walter R.J. Taylor, Didier Menard, Sim Kheng, Nicholas J. White
Other Authors: Mahidol University
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/42021
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spelling th-mahidol.420212019-03-14T15:03:03Z Modelling primaquine-induced haemolysis in G6PD deficiency James Watson Walter R.J. Taylor Didier Menard Sim Kheng Nicholas J. White Mahidol University Nuffield Department of Clinical Medicine Institut Pasteur du Cambodge National Center for Parasitology, Entomology and Malaria Control Biochemistry, Genetics and Molecular Biology Immunology and Microbiology © Watson et al. Primaquine is the only drug available to prevent relapse in vivax malaria. The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd). As testing for G6PDd is often unavailable, this limits the use of primaquine for radical cure. A compartmental model of the dynamics of red blood cell production and destruction was designed to characterise primaquine-induced haemolysis using a holistic Bayesian analysis of all published data and was used to predict a safer alternative to the currently recommended once weekly 0.75 mg/kg regimen for G6PDd. The model suggests that a step-wise increase in daily administered primaquine dose would be relatively safe in G6PDd. If this is confirmed, then were this regimen to be recommended for radical cure patients would not require testing for G6PDd in areas where G6PDd Viangchan or milder variants are prevalent. 2018-12-21T06:54:24Z 2019-03-14T08:03:03Z 2018-12-21T06:54:24Z 2019-03-14T08:03:03Z 2017-02-04 Article eLife. Vol.6, (2017) 10.7554/eLife.23061 2050084X 2-s2.0-85014449955 https://repository.li.mahidol.ac.th/handle/123456789/42021 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85014449955&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
spellingShingle Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
James Watson
Walter R.J. Taylor
Didier Menard
Sim Kheng
Nicholas J. White
Modelling primaquine-induced haemolysis in G6PD deficiency
description © Watson et al. Primaquine is the only drug available to prevent relapse in vivax malaria. The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd). As testing for G6PDd is often unavailable, this limits the use of primaquine for radical cure. A compartmental model of the dynamics of red blood cell production and destruction was designed to characterise primaquine-induced haemolysis using a holistic Bayesian analysis of all published data and was used to predict a safer alternative to the currently recommended once weekly 0.75 mg/kg regimen for G6PDd. The model suggests that a step-wise increase in daily administered primaquine dose would be relatively safe in G6PDd. If this is confirmed, then were this regimen to be recommended for radical cure patients would not require testing for G6PDd in areas where G6PDd Viangchan or milder variants are prevalent.
author2 Mahidol University
author_facet Mahidol University
James Watson
Walter R.J. Taylor
Didier Menard
Sim Kheng
Nicholas J. White
format Article
author James Watson
Walter R.J. Taylor
Didier Menard
Sim Kheng
Nicholas J. White
author_sort James Watson
title Modelling primaquine-induced haemolysis in G6PD deficiency
title_short Modelling primaquine-induced haemolysis in G6PD deficiency
title_full Modelling primaquine-induced haemolysis in G6PD deficiency
title_fullStr Modelling primaquine-induced haemolysis in G6PD deficiency
title_full_unstemmed Modelling primaquine-induced haemolysis in G6PD deficiency
title_sort modelling primaquine-induced haemolysis in g6pd deficiency
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/42021
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