Synthesis, biological evaluation and in silico study of bis-thiourea derivatives as anticancer, antimalarial and antimicrobial agents

• Main Authors: Ratchanok Pingaew, Nujarin Sinthupoom, Prasit Mandi, Veda Prachayasittikul, Rungrot Cherdtrakulkiat, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
• Other Authors: Srinakharinwirot University
• Format: Article
• Published: 2018
• Subjects: Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/42189
• Institution: Mahidol University

© 2017, Springer Science+Business Media, LLC. Two sets of bis-thioureas including a para series (8–14) and a meta series (4, 5, 15–19), were synthesized and evaluated for their anticancer, antimalarial and antimicrobial activities. Most of the synthesized bis-thioureas, except for analogs 8–11, disp...