Oriented conjugation of antibodies against the epithelial cell adhesion molecule on fluorescently doped silica nanoparticles for flow-cytometric determination and in vivo imaging of EpCAM, a biomarker for colorectal cancer

• Main Authors: Kiatnida Treerattrakoon, Warangkana Chanthima, Chayachon Apiwat, Tararaj Dharakul, Suwussa Bamrungsap
• Other Authors: Thailand National Science and Technology Development Agency
• Format: Article
• Published: 2018
• Subjects: Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/42226
• Institution: Mahidol University

© 2017, Springer-Verlag Wien. The authors report on the conjugation of monoclonal antibodies against the biomarker epithelial cell adhesion molecule (EpCAM) to silica nanoparticles doped with the dye Cy5 (Cy5-SiNPs). Conjugation was performed on the Cy5-SiNPs that were previously coated with a layer...