Iodine/TBHP-Promoted One-Pot Deoxygenation and Direct 2-Sulfonylation of Quinoline N-Oxides with Sodium Sulfinates: Facile and Regioselective Synthesis of 2-Sulfonylquinolines

Iodine/TBHP-Promoted One-Pot Deoxygenation and Direct 2-Sulfonylation of Quinoline N-Oxides with Sodium Sulfinates: Facile and Regioselective Synthesis of 2-Sulfonylquinolines

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A highly efficient iodine/TBHP-mediated one-pot deoxygenative and regioselective 2-sulfonylation of quinoline N-oxides with sodium sulfinate salts has been developed. This metal-, base-, and phosphorus-free protocol employs readily accessible a...

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Main Authors: Ladawan Sumunnee, Chonchanok Buathongjan, Chaleena Pimpasri, Sirilata Yotphan
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Chemistry
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/42267
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spelling th-mahidol.422672019-03-14T15:03:19Z Iodine/TBHP-Promoted One-Pot Deoxygenation and Direct 2-Sulfonylation of Quinoline N-Oxides with Sodium Sulfinates: Facile and Regioselective Synthesis of 2-Sulfonylquinolines Ladawan Sumunnee Chonchanok Buathongjan Chaleena Pimpasri Sirilata Yotphan Mahidol University Chemistry © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A highly efficient iodine/TBHP-mediated one-pot deoxygenative and regioselective 2-sulfonylation of quinoline N-oxides with sodium sulfinate salts has been developed. This metal-, base-, and phosphorus-free protocol employs readily accessible and easy-to-handle reagents and can be conveniently carried out at room temperature under mild conditions, providing an alternative access to a series of 2-sulfonylquinolines and other related heteroaryl sulfone products in moderate-to-excellent yields within a short reaction time. 2018-12-21T07:14:34Z 2019-03-14T08:03:19Z 2018-12-21T07:14:34Z 2019-03-14T08:03:19Z 2017-01-01 Article European Journal of Organic Chemistry. Vol.2017, No.5 (2017), 1025-1032 10.1002/ejoc.201601443 10990690 1434193X 2-s2.0-85011969720 https://repository.li.mahidol.ac.th/handle/123456789/42267 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85011969720&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Chemistry
spellingShingle Chemistry
Ladawan Sumunnee
Chonchanok Buathongjan
Chaleena Pimpasri
Sirilata Yotphan
Iodine/TBHP-Promoted One-Pot Deoxygenation and Direct 2-Sulfonylation of Quinoline N-Oxides with Sodium Sulfinates: Facile and Regioselective Synthesis of 2-Sulfonylquinolines
description © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A highly efficient iodine/TBHP-mediated one-pot deoxygenative and regioselective 2-sulfonylation of quinoline N-oxides with sodium sulfinate salts has been developed. This metal-, base-, and phosphorus-free protocol employs readily accessible and easy-to-handle reagents and can be conveniently carried out at room temperature under mild conditions, providing an alternative access to a series of 2-sulfonylquinolines and other related heteroaryl sulfone products in moderate-to-excellent yields within a short reaction time.
author2 Mahidol University
author_facet Mahidol University
Ladawan Sumunnee
Chonchanok Buathongjan
Chaleena Pimpasri
Sirilata Yotphan
format Article
author Ladawan Sumunnee
Chonchanok Buathongjan
Chaleena Pimpasri
Sirilata Yotphan
author_sort Ladawan Sumunnee
title Iodine/TBHP-Promoted One-Pot Deoxygenation and Direct 2-Sulfonylation of Quinoline N-Oxides with Sodium Sulfinates: Facile and Regioselective Synthesis of 2-Sulfonylquinolines
title_short Iodine/TBHP-Promoted One-Pot Deoxygenation and Direct 2-Sulfonylation of Quinoline N-Oxides with Sodium Sulfinates: Facile and Regioselective Synthesis of 2-Sulfonylquinolines
title_full Iodine/TBHP-Promoted One-Pot Deoxygenation and Direct 2-Sulfonylation of Quinoline N-Oxides with Sodium Sulfinates: Facile and Regioselective Synthesis of 2-Sulfonylquinolines
title_fullStr Iodine/TBHP-Promoted One-Pot Deoxygenation and Direct 2-Sulfonylation of Quinoline N-Oxides with Sodium Sulfinates: Facile and Regioselective Synthesis of 2-Sulfonylquinolines
title_full_unstemmed Iodine/TBHP-Promoted One-Pot Deoxygenation and Direct 2-Sulfonylation of Quinoline N-Oxides with Sodium Sulfinates: Facile and Regioselective Synthesis of 2-Sulfonylquinolines
title_sort iodine/tbhp-promoted one-pot deoxygenation and direct 2-sulfonylation of quinoline n-oxides with sodium sulfinates: facile and regioselective synthesis of 2-sulfonylquinolines
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/42267
_version_ 1763487535553576960

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