Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration

© 2017 by ASME. Viewed in renal physiology as a refined filtration device, the glomerulus filters large volumes of blood plasma while keeping proteins within blood circulation. Effects of macromolecule size and macromolecule hydrodynamic interaction with the nanostructure of the cellular layers of t...

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Main Authors: Numpong Punyaratabandhu, Pimkhwan Kongoup, Panadda Dechadilok, Pisut Katavetin, Wannapong Triampo
Other Authors: Chulalongkorn University
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/42551
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spelling th-mahidol.425512019-03-14T15:03:35Z Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration Numpong Punyaratabandhu Pimkhwan Kongoup Panadda Dechadilok Pisut Katavetin Wannapong Triampo Chulalongkorn University Mahidol University Engineering © 2017 by ASME. Viewed in renal physiology as a refined filtration device, the glomerulus filters large volumes of blood plasma while keeping proteins within blood circulation. Effects of macromolecule size and macromolecule hydrodynamic interaction with the nanostructure of the cellular layers of the glomerular capillary wall on the glomerular size selectivity are investigated through a mathematical simulation based on an ultrastructural model. The epithelial slit, a planar arrangement of fibers connecting the epithelial podocytes, is represented as a row of parallel cylinders with nonuniform spacing between adjacent fibers. The mean and standard deviation of gap half-width between its fibers are based on values recently reported from electron microscopy. The glomerular basement membrane (GBM) is represented as a fibrous medium containing fibers of two different sizes: the size of type IV collagens and that of glycosaminoglycans (GAGs). The endothelial cell layer is modeled as a layer full of fenestrae that are much larger than solute size and filled with GAGs. The calculated total sieving coefficient agrees well with the sieving coefficients of ficolls obtained from in vivo urinalysis in humans, whereas the computed glomerular hydraulic permeability also falls within the range estimated from human glomerular filtration rate (GFR). Our result indicates that the endothelial cell layer and GBM significantly contribute to solute and fluid restriction of the glomerular barrier, whereas, based on the structure of the epithelial slit obtained from electron microscopy, the contribution of the epithelial slit could be smaller than previously believed. 2018-12-21T07:32:36Z 2019-03-14T08:03:35Z 2018-12-21T07:32:36Z 2019-03-14T08:03:35Z 2017-12-01 Article Journal of Biomechanical Engineering. Vol.139, No.12 (2017) 10.1115/1.4037550 15288951 01480731 2-s2.0-85030563516 https://repository.li.mahidol.ac.th/handle/123456789/42551 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85030563516&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Engineering
spellingShingle Engineering
Numpong Punyaratabandhu
Pimkhwan Kongoup
Panadda Dechadilok
Pisut Katavetin
Wannapong Triampo
Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration
description © 2017 by ASME. Viewed in renal physiology as a refined filtration device, the glomerulus filters large volumes of blood plasma while keeping proteins within blood circulation. Effects of macromolecule size and macromolecule hydrodynamic interaction with the nanostructure of the cellular layers of the glomerular capillary wall on the glomerular size selectivity are investigated through a mathematical simulation based on an ultrastructural model. The epithelial slit, a planar arrangement of fibers connecting the epithelial podocytes, is represented as a row of parallel cylinders with nonuniform spacing between adjacent fibers. The mean and standard deviation of gap half-width between its fibers are based on values recently reported from electron microscopy. The glomerular basement membrane (GBM) is represented as a fibrous medium containing fibers of two different sizes: the size of type IV collagens and that of glycosaminoglycans (GAGs). The endothelial cell layer is modeled as a layer full of fenestrae that are much larger than solute size and filled with GAGs. The calculated total sieving coefficient agrees well with the sieving coefficients of ficolls obtained from in vivo urinalysis in humans, whereas the computed glomerular hydraulic permeability also falls within the range estimated from human glomerular filtration rate (GFR). Our result indicates that the endothelial cell layer and GBM significantly contribute to solute and fluid restriction of the glomerular barrier, whereas, based on the structure of the epithelial slit obtained from electron microscopy, the contribution of the epithelial slit could be smaller than previously believed.
author2 Chulalongkorn University
author_facet Chulalongkorn University
Numpong Punyaratabandhu
Pimkhwan Kongoup
Panadda Dechadilok
Pisut Katavetin
Wannapong Triampo
format Article
author Numpong Punyaratabandhu
Pimkhwan Kongoup
Panadda Dechadilok
Pisut Katavetin
Wannapong Triampo
author_sort Numpong Punyaratabandhu
title Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration
title_short Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration
title_full Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration
title_fullStr Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration
title_full_unstemmed Transport of Spherical Particles Through Fibrous Media and a Row of Parallel Cylinders: Applications to Glomerular Filtration
title_sort transport of spherical particles through fibrous media and a row of parallel cylinders: applications to glomerular filtration
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/42551
_version_ 1763498192144433152