Roles of D-amino acids on the bioactivity of host defense peptides
© 2016 by the authors; licensee MDPI, Basel, Switzerland. Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast arra...
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| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/42926 |
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| Institution: | Mahidol University |
| Summary: | © 2016 by the authors; licensee MDPI, Basel, Switzerland. Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of D-amino acids (D-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of D-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists. Given the impact that D-AA incorporation has on HDPs, this review aims to fill that void with a systematic discussion of the impact of D-AA on HDPs. |
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