Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax
© 2016 Nature America, Inc. All rights reserved. Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampl...
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th-mahidol.429702019-03-14T15:04:01Z Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax Daniel N. Hupalo Zunping Luo Alexandre Melnikov Patrick L. Sutton Peter Rogov Ananias Escalante Andrés F. Vallejo Sócrates Herrera Myriam Arévalo-Herrera Qi Fan Ying Wang Liwang Cui Carmen M. Lucas Salomon Durand Juan F. Sanchez G. Christian Baldeviano Andres G. Lescano Moses Laman Celine Barnadas Alyssa Barry Ivo Mueller James W. Kazura Alex Eapen Deena Kanagaraj Neena Valecha Marcelo U. Ferreira Wanlapa Roobsoong Wang Nguitragool Jetsumon Sattabonkot Dionicia Gamboa Margaret Kosek Joseph M. Vinetz Lilia González-Cerón Bruce W. Birren Daniel E. Neafsey Jane M. Carlton New York University Broad Institute Temple University Caucaseco Scientific Research Center Universidad del Valle, Cali Dalian Institute of Biotechnology Third Military Medical University Pennsylvania State University US Naval Medical Research Unit No. 6 Papua New Guinea Institute of Medical Research Walter and Eliza Hall Institute of Medical Research University of Melbourne Instituto de Salud Global de Barcelona Case Western Reserve University National Institute of Malaria Research India Universidade de Sao Paulo - USP Mahidol University Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt Universidad Peruana Cayetano Heredia Johns Hopkins Bloomberg School of Public Health University of California, San Diego National Institute for Public Health Biochemistry, Genetics and Molecular Biology © 2016 Nature America, Inc. All rights reserved. Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally. 2018-12-11T02:11:34Z 2019-03-14T08:04:01Z 2018-12-11T02:11:34Z 2019-03-14T08:04:01Z 2016-08-01 Article Nature Genetics. Vol.48, No.8 (2016), 953-958 10.1038/ng.3588 15461718 10614036 2-s2.0-84976273742 https://repository.li.mahidol.ac.th/handle/123456789/42970 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84976273742&origin=inward |
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Biochemistry, Genetics and Molecular Biology Daniel N. Hupalo Zunping Luo Alexandre Melnikov Patrick L. Sutton Peter Rogov Ananias Escalante Andrés F. Vallejo Sócrates Herrera Myriam Arévalo-Herrera Qi Fan Ying Wang Liwang Cui Carmen M. Lucas Salomon Durand Juan F. Sanchez G. Christian Baldeviano Andres G. Lescano Moses Laman Celine Barnadas Alyssa Barry Ivo Mueller James W. Kazura Alex Eapen Deena Kanagaraj Neena Valecha Marcelo U. Ferreira Wanlapa Roobsoong Wang Nguitragool Jetsumon Sattabonkot Dionicia Gamboa Margaret Kosek Joseph M. Vinetz Lilia González-Cerón Bruce W. Birren Daniel E. Neafsey Jane M. Carlton Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax |
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© 2016 Nature America, Inc. All rights reserved. Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally. |
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New York University |
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New York University Daniel N. Hupalo Zunping Luo Alexandre Melnikov Patrick L. Sutton Peter Rogov Ananias Escalante Andrés F. Vallejo Sócrates Herrera Myriam Arévalo-Herrera Qi Fan Ying Wang Liwang Cui Carmen M. Lucas Salomon Durand Juan F. Sanchez G. Christian Baldeviano Andres G. Lescano Moses Laman Celine Barnadas Alyssa Barry Ivo Mueller James W. Kazura Alex Eapen Deena Kanagaraj Neena Valecha Marcelo U. Ferreira Wanlapa Roobsoong Wang Nguitragool Jetsumon Sattabonkot Dionicia Gamboa Margaret Kosek Joseph M. Vinetz Lilia González-Cerón Bruce W. Birren Daniel E. Neafsey Jane M. Carlton |
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Article |
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Daniel N. Hupalo Zunping Luo Alexandre Melnikov Patrick L. Sutton Peter Rogov Ananias Escalante Andrés F. Vallejo Sócrates Herrera Myriam Arévalo-Herrera Qi Fan Ying Wang Liwang Cui Carmen M. Lucas Salomon Durand Juan F. Sanchez G. Christian Baldeviano Andres G. Lescano Moses Laman Celine Barnadas Alyssa Barry Ivo Mueller James W. Kazura Alex Eapen Deena Kanagaraj Neena Valecha Marcelo U. Ferreira Wanlapa Roobsoong Wang Nguitragool Jetsumon Sattabonkot Dionicia Gamboa Margaret Kosek Joseph M. Vinetz Lilia González-Cerón Bruce W. Birren Daniel E. Neafsey Jane M. Carlton |
author_sort |
Daniel N. Hupalo |
title |
Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax |
title_short |
Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax |
title_full |
Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax |
title_fullStr |
Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax |
title_full_unstemmed |
Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax |
title_sort |
population genomics studies identify signatures of global dispersal and drug resistance in plasmodium vivax |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/42970 |
_version_ |
1763496714024517632 |