SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma

• Main Authors: S. Luanpitpong, J. Li, A. Manke, K. Brundage, E. Ellis, S. L. McLaughlin, P. Angsutararux, N. Chanthra, M. Voronkova, Y. C. Chen, L. Wang, P. Chanvorachote, M. Pei, S. Issaragrisil, Y. Rojanasakul
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/42986

© 2016 Macmillan Publishers Limited. Cancer stem cells (CSCs) are a promising target for cancer therapy, particularly for metastatic lung cancers, but how CSCs are regulated is largely unknown. We identify two proteins, SLUG (encoded by SNAI2 gene) and SOX9, which are associated with advanced stage...