Breast cancer upregulating genes in stromal cells by LINE-1 hypermethylation and micrometastatic detection

• Main Authors: Charoenchai Puttipanyalears, Nakarin Kitkumthorn, Supranee Buranapraditkun, Somboon Keelawat, Apiwat Mutirangura
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/43062
• Institution: Mahidol University

© 2016 Future Medicine Ltd. Changes in the methylation level of genes containing LINE-1 alter host gene regulation. Aim: This study demonstrates that paracrine signaling of breast cancer influences the epigenetic regulation of stromal cells. Methods: We proved in vitro and in vivo breast cancer prom...