Structural and biochemical characterization of two heme binding sites on α<inf>1</inf>-microglobulin using site directed mutagenesis and molecular simulation

Structural and biochemical characterization of two heme binding sites on α<inf>1</inf>-microglobulin using site directed mutagenesis and molecular simulation

© 2015 Elsevier B.V. Background α1-Microglobulin (A1M) is a reductase and radical scavenger involved in physiological protection against oxidative damage. These functions were previously shown to be dependent upon cysteinyl-, C34, and lysyl side-chains, K(92, 118,130). A1M binds heme and the crystal...

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Main Authors: Sigurbjörg Rutardottir, Elena Karnaukhova, Chanin Nantasenamat, Napat Songtawee, Virapong Prachayasittikul, Mohsen Rajabi, Lena Wester Rosenlöf, Abdu I. Alayash, Bo Åkerström
Other Authors: Lunds Universitet
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/43218
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/43218

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