Anti-HIV activity of alkaloids from dasymaschalon echinatum

Anti-HIV activity of alkaloids from dasymaschalon echinatum

© 2018 Natural Product Incorporation. All Rights Reserved. Bioassay-guided fractionation of the aerial parts of Dasymaschalon echinatum led to the isolation of five known aristolactams; aristolactam AII (1), aristolactam BII (2), piperolactam A (3), piperolactam C (4), and goniopedaline (5), togethe...

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Bibliographic Details
Main Authors: Samreang Bunteang, Waraporn Chanakul, Sakchai Hongthong, Chutima Kuhakarn, Watcharra Chintakovid, Natthapat Sungchawek, Radeekorn Akkarawongsapat, Jitra Limthongkul, Narong Nantasaen, Vichai Reutrakul, Thaworn Jaipetch
Other Authors: King Mongkut's University of Technology North Bangkok
Format: Article
Published: 2019
Subjects:
Agricultural and Biological Sciences
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/44888
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Institution: Mahidol University
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Summary:© 2018 Natural Product Incorporation. All Rights Reserved. Bioassay-guided fractionation of the aerial parts of Dasymaschalon echinatum led to the isolation of five known aristolactams; aristolactam AII (1), aristolactam BII (2), piperolactam A (3), piperolactam C (4), and goniopedaline (5), together with two aphorphine alkaloids; duguevalline (6) and noraristolodione (7) and two amide derivatives; asperphenamate (8), and N-benzoyl-L-phenylalaninol (9). Alkaloids 2 and 7 were isolated for the first time from the Dasymaschalon genus. The anti-HIV 1 reverse transcriptase (RT) activity of all isolated compounds was determined. Except for aristolactam BII (2), this is the first report of the anti-HIV 1-RT activity of compounds 1 and 3-9. Compounds 1, 3, 5, 6 and 8 showed weak anti-HIV 1-RT inhibitory activity with IC50 ranging from 112.74 to 225.55 M.

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