Potent neutralizing human monoclonal antibodies preferentially target mature dengue virus particles: Implication for novel strategy for dengue vaccine

• Main Authors: Wen Yang Tsai, Hui Ling Chen, Jih Jin Tsai, Wanwisa Dejnirattisai, Amonrat Jumnainsong, Juthathip Mongkolsapaya, Gavin Screaton, James E. Crowe, Wei Kung Wang
• Other Authors: Kaohsiung Medical University Chung-Ho Memorial Hospital
• Format: Article
• Published: 2019
• Subjects: Agricultural and Biological Sciences; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/44918
• Institution: Mahidol University

Copyright © 2018 American Society for Microbiology. All Rights Reserved. The four serotypes of dengue virus (DENV) cause the most important mosquito-borne viral disease in humans. The envelope (E) protein is the major target of neutralizing antibodies and contains 3 domains (domain I [DI], DII, and...