Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Verbal adynamia (impaired language generation, as during conversation) has not been assessed systematically in parkinsonian disorders. We addressed this in patients with Parkinson’s dementia, prog...

Full description

Saved in:
Bibliographic Details
Main Authors: Nadia K. Magdalinou, Hannah L. Golden, Jennifer M. Nicholas, Pirada Witoonpanich, Catherine J. Mummery, Huw R. Morris, Atbin Djamshidian, Tom T. Warner, Elizabeth K. Warrington, Andrew J. Lees, Jason D. Warren
Other Authors: London School of Hygiene & Tropical Medicine
Format: Article
Published: 2019
Subjects:
Arts and Humanities
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/44924
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Mahidol University
Description
Summary:© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Verbal adynamia (impaired language generation, as during conversation) has not been assessed systematically in parkinsonian disorders. We addressed this in patients with Parkinson’s dementia, progressive supranuclear palsy and corticobasal degeneration. All disease groups showed impaired verbal fluency and sentence generation versus healthy age-matched controls, after adjusting for general linguistic and executive factors. Dopaminergic stimulation in the Parkinson’s group selectively improved verbal generation versus other cognitive functions. Voxel-based morphometry identified left inferior frontal and posterior superior temporal cortical correlates of verbal generation performance. Verbal adynamia warrants further evaluation as an index of language network dysfunction and dopaminergic state in parkinsonian disorders.

Similar Items