Targeting GLP-1 receptor trafficking to improve agonist efficacy

Targeting GLP-1 receptor trafficking to improve agonist efficacy

© 2018 The Author(s). Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important pharmacological target in type 2 diabetes (T2D). Like other G protein-coupled receptors, the GLP-1R undergoes agonist-mediated end...

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Bibliographic Details
Main Authors: Ben Jones, Teresa Buenaventura, Nisha Kanda, Pauline Chabosseau, Bryn M. Owen, Rebecca Scott, Robert Goldin, Napat Angkathunyakul, Ivan R. Corrêa, Domenico Bosco, Paul R. Johnson, Lorenzo Piemonti, Piero Marchetti, A. M.James Shapiro, Blake J. Cochran, Aylin C. Hanyaloglu, Asuka Inoue, Tricia Tan, Guy A. Rutter, Alejandra Tomas, Stephen R. Bloom
Other Authors: IRCCS San Raffaele Scientific Institute
Format: Article
Published: 2019
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Physics and Astronomy
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/44986
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/44986

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