Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
© 2018 The Author(s). The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its...
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th-mahidol.449922019-08-28T13:56:45Z Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages Evelien M. Bunnik Kate B. Cook Nelle Varoquaux Gayani Batugedara Jacques Prudhomme Anthony Cort Lirong Shi Chiara Andolina Leila S. Ross Declan Brady David A. Fidock Francois Nosten Rita Tewari Photini Sinnis Ferhat Ay Jean Philippe Vert William Stafford Noble Karine G. Le Roch Département de Mathématiques et Applications Institut Curie Mines ParisTech Columbia University in the City of New York University of California, Riverside Columbia University Medical Center University of Oxford University of California, Berkeley University of Texas Health Science Center at San Antonio University of Washington, Seattle University of Nottingham La Jolla Institute for Allergy and Immunology Mahidol University Johns Hopkins Bloomberg School of Public Health Inserm Berkeley Global Science Institute Biochemistry, Genetics and Molecular Biology Chemistry Physics and Astronomy © 2018 The Author(s). The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathogenesis and immune evasion, host cell invasion, sexual differentiation, and master regulation of gene expression. Furthermore, we observe reorganization of subtelomeric heterochromatin around genes involved in host cell remodeling. Depletion of heterochromatin protein 1 (PfHP1) resulted in loss of interactions between virulence genes, confirming that PfHP1 is essential for maintenance of the repressive center. Our results suggest that the three-dimensional genome structure of human malaria parasites is strongly connected with transcriptional activity of specific gene families throughout the life cycle. 2019-08-23T10:25:39Z 2019-08-23T10:25:39Z 2018-12-01 Article Nature Communications. Vol.9, No.1 (2018) 10.1038/s41467-018-04295-5 20411723 2-s2.0-85047179219 https://repository.li.mahidol.ac.th/handle/123456789/44992 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047179219&origin=inward |
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Biochemistry, Genetics and Molecular Biology Chemistry Physics and Astronomy Evelien M. Bunnik Kate B. Cook Nelle Varoquaux Gayani Batugedara Jacques Prudhomme Anthony Cort Lirong Shi Chiara Andolina Leila S. Ross Declan Brady David A. Fidock Francois Nosten Rita Tewari Photini Sinnis Ferhat Ay Jean Philippe Vert William Stafford Noble Karine G. Le Roch Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
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© 2018 The Author(s). The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathogenesis and immune evasion, host cell invasion, sexual differentiation, and master regulation of gene expression. Furthermore, we observe reorganization of subtelomeric heterochromatin around genes involved in host cell remodeling. Depletion of heterochromatin protein 1 (PfHP1) resulted in loss of interactions between virulence genes, confirming that PfHP1 is essential for maintenance of the repressive center. Our results suggest that the three-dimensional genome structure of human malaria parasites is strongly connected with transcriptional activity of specific gene families throughout the life cycle. |
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Département de Mathématiques et Applications |
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Département de Mathématiques et Applications Evelien M. Bunnik Kate B. Cook Nelle Varoquaux Gayani Batugedara Jacques Prudhomme Anthony Cort Lirong Shi Chiara Andolina Leila S. Ross Declan Brady David A. Fidock Francois Nosten Rita Tewari Photini Sinnis Ferhat Ay Jean Philippe Vert William Stafford Noble Karine G. Le Roch |
format |
Article |
author |
Evelien M. Bunnik Kate B. Cook Nelle Varoquaux Gayani Batugedara Jacques Prudhomme Anthony Cort Lirong Shi Chiara Andolina Leila S. Ross Declan Brady David A. Fidock Francois Nosten Rita Tewari Photini Sinnis Ferhat Ay Jean Philippe Vert William Stafford Noble Karine G. Le Roch |
author_sort |
Evelien M. Bunnik |
title |
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
title_short |
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
title_full |
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
title_fullStr |
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
title_full_unstemmed |
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
title_sort |
changes in genome organization of parasite-specific gene families during the plasmodium transmission stages |
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2019 |
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https://repository.li.mahidol.ac.th/handle/123456789/44992 |
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1763494651258470400 |