CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites

• Main Authors: Robert C. Tuckey, Wei Li, Dejian Ma, Chloe Y.S. Cheng, Katie M. Wang, Tae Kang Kim, Saowanee Jeayeng, Andrzej T. Slominski
• Other Authors: Birmingham VA Medical Center
• Format: Article
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/45126
• Institution: Mahidol University

© 2018 Elsevier Ltd Prolonged exposure of the skin to UV radiation causes previtamin D3, the initial photoproduct formed by opening of the B ring of 7-dehydrocholesterol, to undergo a second photochemical reaction where the B-ring is reformed giving lumisterol3 (L3), a stereoisomer of 7-dehydrochol...