Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome

Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome

© 2018 2018 Future Medicine Ltd. Aim: To investigate the relationship of Vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GC-globulin concentrations were measured by quantitative...

Full description

Saved in:
Bibliographic Details
Main Authors: Piyaporn Karuwanarint, Benjaluck Phonrat, Anchalee Tungtrongchitr, Kanjana Suriyaprom, Somlak Chuengsamarn, Florian J. Schweigert, Rungsunn Tungtrongchitr
Other Authors: Rangsit University
Format: Article
Published: 2019
Subjects:
Biochemistry, Genetics and Molecular Biology
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/45182
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Mahidol University
Description
Summary:© 2018 2018 Future Medicine Ltd. Aim: To investigate the relationship of Vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-Type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.

Similar Items