Controlled rapid synthesis and in vivo immunomodulatory effects of LM α(1,6)mannan with an amine linker

• Main Authors: Warunda Bunthitsakda, Haris Leelayuwapan, Jiraporn Paha, Niwat Kangwanrangsan, Runglawan Chawengkirttikul, Marisa Ponpuak, Somsak Ruchirawat, Siwarutt Boonyarattanakalin
• Other Authors: Chulabhorn Research Institute
• Format: Article
• Published: 2019
• Subjects: Chemistry; Materials Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/45479
• Institution: Mahidol University

© 2018 Elsevier Ltd The synthetic lipomannan (LM) α(1,6)mannans, already equipped with an amine linker on the reducing end, are rapidly synthesized in a size-, regio-, and stereocontrolled reaction. The size of the mannans is regulated through the concentration of the linker, applied during the cont...