Integrin α<inf>4</inf>β<inf>7</inf> Blockade Preferentially Impacts CCR6⁺ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques

• Main Authors: Giulia Calenda, Rassamon Keawvichit, Géraldine Arrode-Brusés, Kovit Pattanapanyasat, Ines Frank, Siddappa N. Byrareddy, James Arthos, Claudia Cicala, Brooke Grasperge, James L. Blanchard, Agegnehu Gettie, Keith A. Reimann, Aftab A. Ansari, Elena Martinelli
• Other Authors: Tulane National Primate Research Center
• Format: Article
• Published: 2019
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/46055
• Institution: Mahidol University

Copyright © 2018 by The American Association of Immunologists, Inc. Infusion of a simianized anti-α4β7 mAb (Rh-α4β7) just before and following SIV infection protected rhesus macaques from developing AIDS and partially from vaginal SIV acquisition. Recently, short-term treatment with Rh-α4β7 in combi...