Estradiol treatment initiated early after ovariectomy regulates myocardial gene expression and inhibits diastolic dysfunction in female cynomolgus monkeys: Potential roles for calcium homeostasis and extracellular matrix remodeling

Estradiol treatment initiated early after ovariectomy regulates myocardial gene expression and inhibits diastolic dysfunction in female cynomolgus monkeys: Potential roles for calcium homeostasis and extracellular matrix remodeling

© 2018 The Authors. Background—Left ventricular (LV) diastolic dysfunction often precedes heart failure with preserved ejection fraction, the dominant form of heart failure in postmenopausal women. The objective of this study was to determine the effect of oral estradiol treatment initiated early af...

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Bibliographic Details
Main Authors: Kristofer T. Michalson, Leanne Groban, Timothy D. Howard, Carol A. Shively, Areepan Sophonsritsuk, Susan E. Appt, J. Mark Cline, Thomas B. Clarkson, J. Jeffrey Carr, Dalane W. Kitzman, Thomas C. Register
Other Authors: Wake Forest University School of Medicine
Format: Article
Published: 2019
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/46210
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/46210

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