Activation of coagulation and endothelium with concurrent impairment of anticoagulant mechanisms in patients with typhoid fever

• Main Authors: Hanna K. de Jong, Chris M. Parry, Thomas W. van der Vaart, Liesbeth M. Kager, Stannie J. van den Ende, Rapeephan R. Maude, Lalith Wijedoru, Aniruddha Ghose, Mohammed U. Hassan, Mohammed A. Hossain, Arjan M. Dondorp, Steve Baker, M. Abul Faiz, Joost C.M. Meijers, W. Joost Wiersinga
• Other Authors: Churchill Hospital
• Format: Article
• Published: 2019
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/46578
• Institution: Mahidol University

© 2018 The Authors Objectives: Typhoid fever caused by Salmonella Typhi remains a major burden worldwide. Gastrointestinal bleeding can be seen in up to 10 percent of patients and may be fatal. The coagulopathy, which may be the driver of this severe complication in patients with typhoid fever, howe...