Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016

© 2018 The American Society for Blood and Marrow Transplantation The resurgence of haploidentical stem cell transplantation (HaploSCT) over the last decade is one of the most important advances in the field of hematopoietic stem cell transplantation (HSCT). The modified platforms of T cell depletio...

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Main Authors: Monzr M. Al Malki, Richard Jones, Qing Ma, Dean Lee, Yair Reisner, Jeffrey S. Miller, Peter Lang, Suradej Hongeng, Parameswaran Hari, Samuel Strober, Jianhua Yu, Richard Maziarz, Domenico Mavilio, Denis Claude Roy, Chiara Bonini, Richard E. Champlin, Ephraim J. Fuchs, Stefan O. Ciurea
Other Authors: Humanitas University
Format: Conference or Workshop Item
Published: 2019
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/46743
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spelling th-mahidol.467432019-08-28T13:13:00Z Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016 Monzr M. Al Malki Richard Jones Qing Ma Dean Lee Yair Reisner Jeffrey S. Miller Peter Lang Suradej Hongeng Parameswaran Hari Samuel Strober Jianhua Yu Richard Maziarz Domenico Mavilio Denis Claude Roy Chiara Bonini Richard E. Champlin Ephraim J. Fuchs Stefan O. Ciurea Humanitas University IRCCS San Raffaele Scientific Institute Stanford University School of Medicine Università degli Studi di Milano University of Minnesota Twin Cities Universitätsklinikum Tübingen Medizinische Fakultät The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Weizmann Institute of Science Israel Oregon Health and Science University University of Texas MD Anderson Cancer Center Mahidol University Medical College of Wisconsin Hopital Maisonneuve-Rosemont City of Hope National Med Center Ohio State University Children's Hospital Columbus Medicine © 2018 The American Society for Blood and Marrow Transplantation The resurgence of haploidentical stem cell transplantation (HaploSCT) over the last decade is one of the most important advances in the field of hematopoietic stem cell transplantation (HSCT). The modified platforms of T cell depletion either ex vivo (CD34 + cell selection, “megadoses” of purified CD34 + cells, or selective depletion of T cells) or newer platforms of in vivo depletion of T cells, with either post-transplantation high-dose cyclophosphamide or intensified immune suppression, have contributed to better outcomes, with survival similar to that in HLA-matched donor transplantation. Further efforts are underway to control viral reactivation using modified T cells, improve immunologic reconstitution, and decrease the relapse rate post-transplantation using donor-derived cellular therapy products, such as genetically modified donor lymphocytes and natural killer cells. Improvements in treatment-related mortality have allowed the extension of haploidentical donor transplants to patients with hemoglobinopathies, such as thalassemia and sickle cell disease, and the possible development of platforms for immunotherapy in solid tumors. Moreover, combining HSCT from a related donor with solid organ transplantation could allow early tapering of immunosuppression in recipients of solid organ transplants and hopefully prevent organ rejection in this setting. This symposium summarizes some of the most important recent advances in HaploSCT and provides a glimpse in the future of fast growing field. 2019-08-28T06:13:00Z 2019-08-28T06:13:00Z 2018-05-01 Conference Paper Biology of Blood and Marrow Transplantation. Vol.24, No.5 (2018), 895-908 10.1016/j.bbmt.2018.01.008 15236536 10838791 2-s2.0-85041640816 https://repository.li.mahidol.ac.th/handle/123456789/46743 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041640816&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Monzr M. Al Malki
Richard Jones
Qing Ma
Dean Lee
Yair Reisner
Jeffrey S. Miller
Peter Lang
Suradej Hongeng
Parameswaran Hari
Samuel Strober
Jianhua Yu
Richard Maziarz
Domenico Mavilio
Denis Claude Roy
Chiara Bonini
Richard E. Champlin
Ephraim J. Fuchs
Stefan O. Ciurea
Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016
description © 2018 The American Society for Blood and Marrow Transplantation The resurgence of haploidentical stem cell transplantation (HaploSCT) over the last decade is one of the most important advances in the field of hematopoietic stem cell transplantation (HSCT). The modified platforms of T cell depletion either ex vivo (CD34 + cell selection, “megadoses” of purified CD34 + cells, or selective depletion of T cells) or newer platforms of in vivo depletion of T cells, with either post-transplantation high-dose cyclophosphamide or intensified immune suppression, have contributed to better outcomes, with survival similar to that in HLA-matched donor transplantation. Further efforts are underway to control viral reactivation using modified T cells, improve immunologic reconstitution, and decrease the relapse rate post-transplantation using donor-derived cellular therapy products, such as genetically modified donor lymphocytes and natural killer cells. Improvements in treatment-related mortality have allowed the extension of haploidentical donor transplants to patients with hemoglobinopathies, such as thalassemia and sickle cell disease, and the possible development of platforms for immunotherapy in solid tumors. Moreover, combining HSCT from a related donor with solid organ transplantation could allow early tapering of immunosuppression in recipients of solid organ transplants and hopefully prevent organ rejection in this setting. This symposium summarizes some of the most important recent advances in HaploSCT and provides a glimpse in the future of fast growing field.
author2 Humanitas University
author_facet Humanitas University
Monzr M. Al Malki
Richard Jones
Qing Ma
Dean Lee
Yair Reisner
Jeffrey S. Miller
Peter Lang
Suradej Hongeng
Parameswaran Hari
Samuel Strober
Jianhua Yu
Richard Maziarz
Domenico Mavilio
Denis Claude Roy
Chiara Bonini
Richard E. Champlin
Ephraim J. Fuchs
Stefan O. Ciurea
format Conference or Workshop Item
author Monzr M. Al Malki
Richard Jones
Qing Ma
Dean Lee
Yair Reisner
Jeffrey S. Miller
Peter Lang
Suradej Hongeng
Parameswaran Hari
Samuel Strober
Jianhua Yu
Richard Maziarz
Domenico Mavilio
Denis Claude Roy
Chiara Bonini
Richard E. Champlin
Ephraim J. Fuchs
Stefan O. Ciurea
author_sort Monzr M. Al Malki
title Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016
title_short Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016
title_full Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016
title_fullStr Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016
title_full_unstemmed Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016
title_sort proceedings from the fourth haploidentical stem cell transplantation symposium (haplo2016), san diego, california, december 1, 2016
publishDate 2019
url https://repository.li.mahidol.ac.th/handle/123456789/46743
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