Malaria
© 2018 Elsevier Ltd Following unsuccessful eradication attempts there was a resurgence of malaria towards the end of the 20th century. Renewed control efforts using a range of improved tools, such as long-lasting insecticide-treated bednets and artemisinin-based combination therapies, have more than...
Saved in:
Main Authors: | , , |
---|---|
Other Authors: | |
Format: | Review |
Published: |
2019
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/46749 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.46749 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.467492019-08-28T13:13:26Z Malaria Elizabeth A. Ashley Aung Pyae Phyo Charles J. Woodrow Shoklo Malaria Research Unit Mahidol University Nuffield Department of Clinical Medicine Myanmar Medicine © 2018 Elsevier Ltd Following unsuccessful eradication attempts there was a resurgence of malaria towards the end of the 20th century. Renewed control efforts using a range of improved tools, such as long-lasting insecticide-treated bednets and artemisinin-based combination therapies, have more than halved the global burden of disease, but it remains high with 445 000 deaths and more than 200 million cases in 2016. Pitfalls in individual patient management are delayed diagnosis and overzealous fluid resuscitation in severe malaria. Even in the absence of drug resistance, parasite recurrence can occur, owing to high parasite densities, low host immunity, or suboptimal drug concentrations. Malaria elimination is firmly back as a mainstream policy but resistance to the artemisinin derivatives, their partner drugs, and insecticides present major challenges. Vaccine development continues on several fronts but none of the candidates developed to date have been shown to provide long-lasting benefits at a population level. Increased resources and unprecedented levels of regional cooperation and societal commitment will be needed if further substantial inroads into the malaria burden are to be made. 2019-08-28T06:13:26Z 2019-08-28T06:13:26Z 2018-04-21 Review The Lancet. Vol.391, No.10130 (2018), 1608-1621 10.1016/S0140-6736(18)30324-6 1474547X 01406736 2-s2.0-85045580319 https://repository.li.mahidol.ac.th/handle/123456789/46749 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045580319&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Medicine |
spellingShingle |
Medicine Elizabeth A. Ashley Aung Pyae Phyo Charles J. Woodrow Malaria |
description |
© 2018 Elsevier Ltd Following unsuccessful eradication attempts there was a resurgence of malaria towards the end of the 20th century. Renewed control efforts using a range of improved tools, such as long-lasting insecticide-treated bednets and artemisinin-based combination therapies, have more than halved the global burden of disease, but it remains high with 445 000 deaths and more than 200 million cases in 2016. Pitfalls in individual patient management are delayed diagnosis and overzealous fluid resuscitation in severe malaria. Even in the absence of drug resistance, parasite recurrence can occur, owing to high parasite densities, low host immunity, or suboptimal drug concentrations. Malaria elimination is firmly back as a mainstream policy but resistance to the artemisinin derivatives, their partner drugs, and insecticides present major challenges. Vaccine development continues on several fronts but none of the candidates developed to date have been shown to provide long-lasting benefits at a population level. Increased resources and unprecedented levels of regional cooperation and societal commitment will be needed if further substantial inroads into the malaria burden are to be made. |
author2 |
Shoklo Malaria Research Unit |
author_facet |
Shoklo Malaria Research Unit Elizabeth A. Ashley Aung Pyae Phyo Charles J. Woodrow |
format |
Review |
author |
Elizabeth A. Ashley Aung Pyae Phyo Charles J. Woodrow |
author_sort |
Elizabeth A. Ashley |
title |
Malaria |
title_short |
Malaria |
title_full |
Malaria |
title_fullStr |
Malaria |
title_full_unstemmed |
Malaria |
title_sort |
malaria |
publishDate |
2019 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/46749 |
_version_ |
1763490843086290944 |