Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula

© 2018 International Neuromodulation Society Objective: To evaluate the safety and efficacy of low-frequency, inhibitory, deep rTMS with a novel H-coil specifically designed to stimulate the insula. Methods: In a randomized, crossover order, 16 healthy volunteers underwent two sessions (sham; active...

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Main Authors: Primavera A. Spagnolo, Han Wang, Prachaya Srivanitchapoom, Melanie Schwandt, Markus Heilig, Mark Hallett
Other Authors: National Institute on Alcohol Abuse and Alcoholism
Published: 2019
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/47227
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spelling th-mahidol.472272019-08-28T13:43:57Z Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula Primavera A. Spagnolo Han Wang Prachaya Srivanitchapoom Melanie Schwandt Markus Heilig Mark Hallett National Institute on Alcohol Abuse and Alcoholism National Institute of Neurological Disorders and Stroke Faculty of Medicine, Siriraj Hospital, Mahidol University Linköpings universitet Peking Union Medical College Medicine Neuroscience © 2018 International Neuromodulation Society Objective: To evaluate the safety and efficacy of low-frequency, inhibitory, deep rTMS with a novel H-coil specifically designed to stimulate the insula. Methods: In a randomized, crossover order, 16 healthy volunteers underwent two sessions (sham; active) of 1 Hz repetitive TMS at an intensity of 120% of individual motor threshold, over the right anterior insular cortex localized using a neuronavigation system. Before, immediately after, and one hour after rTMS, subjects performed two tasks that have previously been shown in fMRI experiments to activate insular cortex: A blink suppression task and a forced-choice risk-taking task. Results: No drop-outs or adverse events occurred. Active deep rTMS did not result in decreased urge to blink compared to sham. Similarly, no significant time × condition interaction on risk-taking behavior was found. Conclusions: Low-frequency deep rTMS using a novel H8 coil was shown to be safe but did not affect any of the behavioral markers, also used to investigate modulation of insula activity. Our findings highlight the challenges of modulating the activity of deep brain regions with TMS. Further studies are necessary to identify effective stimulation parameters for deep targets, and to characterize the effects of deep TMS on overlying cortical regions. 2019-08-28T06:39:19Z 2019-08-28T06:39:19Z 2018-01-01 Neuromodulation. (2018) 10.1111/ner.12875 15251403 10947159 2-s2.0-85055718863 https://repository.li.mahidol.ac.th/handle/123456789/47227 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055718863&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
Neuroscience
spellingShingle Medicine
Neuroscience
Primavera A. Spagnolo
Han Wang
Prachaya Srivanitchapoom
Melanie Schwandt
Markus Heilig
Mark Hallett
Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula
description © 2018 International Neuromodulation Society Objective: To evaluate the safety and efficacy of low-frequency, inhibitory, deep rTMS with a novel H-coil specifically designed to stimulate the insula. Methods: In a randomized, crossover order, 16 healthy volunteers underwent two sessions (sham; active) of 1 Hz repetitive TMS at an intensity of 120% of individual motor threshold, over the right anterior insular cortex localized using a neuronavigation system. Before, immediately after, and one hour after rTMS, subjects performed two tasks that have previously been shown in fMRI experiments to activate insular cortex: A blink suppression task and a forced-choice risk-taking task. Results: No drop-outs or adverse events occurred. Active deep rTMS did not result in decreased urge to blink compared to sham. Similarly, no significant time × condition interaction on risk-taking behavior was found. Conclusions: Low-frequency deep rTMS using a novel H8 coil was shown to be safe but did not affect any of the behavioral markers, also used to investigate modulation of insula activity. Our findings highlight the challenges of modulating the activity of deep brain regions with TMS. Further studies are necessary to identify effective stimulation parameters for deep targets, and to characterize the effects of deep TMS on overlying cortical regions.
author2 National Institute on Alcohol Abuse and Alcoholism
author_facet National Institute on Alcohol Abuse and Alcoholism
Primavera A. Spagnolo
Han Wang
Prachaya Srivanitchapoom
Melanie Schwandt
Markus Heilig
Mark Hallett
author Primavera A. Spagnolo
Han Wang
Prachaya Srivanitchapoom
Melanie Schwandt
Markus Heilig
Mark Hallett
author_sort Primavera A. Spagnolo
title Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula
title_short Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula
title_full Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula
title_fullStr Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula
title_full_unstemmed Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula
title_sort lack of target engagement following low-frequency deep transcranial magnetic stimulation of the anterior insula
publishDate 2019
url https://repository.li.mahidol.ac.th/handle/123456789/47227
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