In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β

• Main Authors: Theerut Luangmonkong, Su Suriguga, Adhyatmika Adhyatmika, Amirah Adlia, Dorenda Oosterhuis, Chuthamanee Suthisisang, Koert P. de Jong, Henricus A.M. Mutsaers, Peter Olinga
• Other Authors: Aarhus Universitet
• Format: Article
• Published: 2019
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/47297
• Institution: Mahidol University

© 2018 Elsevier Inc. Fibrosis is a pathophysiological state characterized by the excessive formation/deposition of fibrous extracellular matrix. Transforming growth factor-beta (TGF-β) is a central profibrotic mediator, and targeting TGF-β is a promising strategy in the development of drugs for the...