Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis

• Main Authors: Perawatt Akara-Amornthum, Thanpisit Lomphithak, Swati Choksi, Rutaiwan Tohtong, Siriporn Jitkaew
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2020
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/49526
• Institution: Mahidol University

Cholangiocarcinoma (CCA), a malignant tumor originating in the biliary tract, is well known to be associated with adverse clinical outcomes and high mortality rates due to the lack of effective therapy. Evasion of apoptosis is considered a key contributor to therapeutic success and chemotherapy resi...