Paper-based sol-gel thin films immobilized cytochrome P450 for enzyme activity measurement

• Main Authors: Nantana Nuchtavorn, Jiraporn Leanpolchareanchai, Leena Suntornsuk, Mirek Macka
• Other Authors: Brno University of Technology, Central European Institute of Technology
• Format: Article
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Environmental Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/49533
• Institution: Mahidol University

© 2019 Elsevier B.V. Cytochrome P450 (CYP450), and in particular CYP3A4, is the most abundantly expressed CYP450 isozyme implicated in many drug-drug and medicinal plant-drug interactions. Therefore, incorporation of CYP3A4 enzyme screening at an early stage of drug discovery is preferable in order...