EP300 and SIRT1/6 co-regulate lapatinib sensitivity via modulating FOXO3-acetylation and activity in breast cancer

EP300 and SIRT1/6 co-regulate lapatinib sensitivity via modulating FOXO3-acetylation and activity in breast cancer

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Forkhead Box O3 (FOXO3) is a tumor suppressor whose activity is fine-tuned by post-translational modifications (PTMs). In this study, using the BT474 breast cancer cells and a recently established lapatinib resistant (BT474-LapR) cell line, w...

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Main Authors: Zimam Mahmud, Ana R. Gomes, Hee Jin Lee, Sathid Aimjongjun, Yannasittha Jiramongkol, Shang Yao, Stefania Zona, Glowi Alasiri, Gyungyub Gong, Ernesto Yagüe, Eric W.F. Lam
Other Authors: Imperial College London
Format: Article
Published: 2020
Subjects:
Biochemistry, Genetics and Molecular Biology
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/50115
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/50115

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