The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes

© 2019 The Authors Aims: Type 2 diabetes mellitus (T2DM)and obstructive sleep apnea (OSA)may adversely affect bone. Gender is a well-established factor influencing bone health. We investigated the impact of OSA on bone mineral density (BMD)and trabecular bone score (TBS)in T2DM. Methods: Eighty-one...

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Main Authors: Hataikarn Nimitphong, Nantaporn Siwasaranond, Chanika Sritara, Sunee Saetung, La or Chailurkit, Naricha Chirakalwasan, Boonsong Ongphiphadhanakul, Sirimon Reutrakul
Other Authors: Chulalongkorn University
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Published: 2020
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/50165
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spelling th-mahidol.501652020-01-27T16:47:41Z The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes Hataikarn Nimitphong Nantaporn Siwasaranond Chanika Sritara Sunee Saetung La or Chailurkit Naricha Chirakalwasan Boonsong Ongphiphadhanakul Sirimon Reutrakul Chulalongkorn University University of Illinois at Chicago King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University Faculty of Medicine, Ramathibodi Hospital, Mahidol University Biochemistry, Genetics and Molecular Biology Medicine © 2019 The Authors Aims: Type 2 diabetes mellitus (T2DM)and obstructive sleep apnea (OSA)may adversely affect bone. Gender is a well-established factor influencing bone health. We investigated the impact of OSA on bone mineral density (BMD)and trabecular bone score (TBS)in T2DM. Methods: Eighty-one T2DM patients [33 men and 48 women]participated. OSA was diagnosed using an overnight monitor, with its severity assessed by an apnea hypopnia index (pAHI). The measurements of hypoxia, including the percentage of total sleep time in which oxygen saturation remains below 90% (pT90), the oxygen desaturation index (pODI)and minimum O2 (min O2), were reported. Lumbar spine (L1-4)and femoral neck (FN)BMD were measured using dual-energy X-ray absorptiometry (DXA). TBS was computed from DXA images. Results: Sixty-five patients (80.2%)had OSA. pAHI, pT90, pODI and min O2 were not correlated to L1-4 BMD, FN BMD or TBS in all participants by multiple regression analyses adjusting for age, gender and BMI. However, an interaction between gender and pAHI, and gender and pODI were significantly associated with TBS (b = 0.003, p = 0.034 and b = 0.004, p = 0.046, respectively). We therefore reassessed an association between pAHI or pODI and TBS separately between men and women. After adjusting for age and BMI, more severe OSA (higher pAHI)and higher pODI significantly associated with lower TBS (b = −0.002, p = 0.034 and b = −0.003, p = 0.021, respectively)in men. On the other hand, higher pAHI non-significantly associated with better trabecular microarchitecture as indicated by higher TBS (b = 0.002, p = 0.059)in women. When considered only postmenopausal (n = 33), higher pAHI and higher pODI were significantly associated with higher TBS (b = 0.004, p = 0.003 and b = 0.004, p = 0.008, respectively). Conclusions: In T2DM patients, there is a complex interrelationship among OSA severity, gender and TBS. More severe OSA predicted lower TBS in men, but predicted higher TBS in postmenopausal women. 2020-01-27T07:43:35Z 2020-01-27T07:43:35Z 2019-06-01 Article Journal of Clinical and Translational Endocrinology. Vol.16, (2019) 10.1016/j.jcte.2019.100193 22146237 2-s2.0-85065448012 https://repository.li.mahidol.ac.th/handle/123456789/50165 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85065448012&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Hataikarn Nimitphong
Nantaporn Siwasaranond
Chanika Sritara
Sunee Saetung
La or Chailurkit
Naricha Chirakalwasan
Boonsong Ongphiphadhanakul
Sirimon Reutrakul
The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
description © 2019 The Authors Aims: Type 2 diabetes mellitus (T2DM)and obstructive sleep apnea (OSA)may adversely affect bone. Gender is a well-established factor influencing bone health. We investigated the impact of OSA on bone mineral density (BMD)and trabecular bone score (TBS)in T2DM. Methods: Eighty-one T2DM patients [33 men and 48 women]participated. OSA was diagnosed using an overnight monitor, with its severity assessed by an apnea hypopnia index (pAHI). The measurements of hypoxia, including the percentage of total sleep time in which oxygen saturation remains below 90% (pT90), the oxygen desaturation index (pODI)and minimum O2 (min O2), were reported. Lumbar spine (L1-4)and femoral neck (FN)BMD were measured using dual-energy X-ray absorptiometry (DXA). TBS was computed from DXA images. Results: Sixty-five patients (80.2%)had OSA. pAHI, pT90, pODI and min O2 were not correlated to L1-4 BMD, FN BMD or TBS in all participants by multiple regression analyses adjusting for age, gender and BMI. However, an interaction between gender and pAHI, and gender and pODI were significantly associated with TBS (b = 0.003, p = 0.034 and b = 0.004, p = 0.046, respectively). We therefore reassessed an association between pAHI or pODI and TBS separately between men and women. After adjusting for age and BMI, more severe OSA (higher pAHI)and higher pODI significantly associated with lower TBS (b = −0.002, p = 0.034 and b = −0.003, p = 0.021, respectively)in men. On the other hand, higher pAHI non-significantly associated with better trabecular microarchitecture as indicated by higher TBS (b = 0.002, p = 0.059)in women. When considered only postmenopausal (n = 33), higher pAHI and higher pODI were significantly associated with higher TBS (b = 0.004, p = 0.003 and b = 0.004, p = 0.008, respectively). Conclusions: In T2DM patients, there is a complex interrelationship among OSA severity, gender and TBS. More severe OSA predicted lower TBS in men, but predicted higher TBS in postmenopausal women.
author2 Chulalongkorn University
author_facet Chulalongkorn University
Hataikarn Nimitphong
Nantaporn Siwasaranond
Chanika Sritara
Sunee Saetung
La or Chailurkit
Naricha Chirakalwasan
Boonsong Ongphiphadhanakul
Sirimon Reutrakul
format Article
author Hataikarn Nimitphong
Nantaporn Siwasaranond
Chanika Sritara
Sunee Saetung
La or Chailurkit
Naricha Chirakalwasan
Boonsong Ongphiphadhanakul
Sirimon Reutrakul
author_sort Hataikarn Nimitphong
title The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
title_short The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
title_full The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
title_fullStr The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
title_full_unstemmed The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
title_sort differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
publishDate 2020
url https://repository.li.mahidol.ac.th/handle/123456789/50165
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