Amides and flavonoids from the fruit and leaf extracts of melodorum siamensis
© 2019 American Chemical Society and American Society of Pharmacognosy. Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) a...
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| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/50251 |
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| Institution: | Mahidol University |
| Summary: | © 2019 American Chemical Society and American Society of Pharmacognosy. Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) and 2 (er 1.1:1) were scalemic and were resolved to yield -1 and (+)-1 and -2 and (+)-2, respectively. The absolute configurations of these compounds were determined from experimental and calculated ECD data. The structures and configurations of -2 and (+)-8 were identified by single-crystal X-ray diffraction analysis. Compound 11 showed nuclear factor-B inhibitory effects (IC 50 = 9 μM) in a pancreatic β cell line (MIN-6 cells). |
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