Antiviral drugs and acute kidney injury (AKI)
© 2019 Bentham Science Publishers. The introduction of more efficient antiviral drugs are common cause drug-induced acute kidney injury (AKI). The true prevalence of antiviral drugs induced nephrotoxicity is hardly determined. It causes AKI by many mechanisms including acute tubular necrosis (ATN),...
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th-mahidol.503072020-01-27T17:15:24Z Antiviral drugs and acute kidney injury (AKI) Wattana Leowattana Mahidol University Biochemistry, Genetics and Molecular Biology Medicine © 2019 Bentham Science Publishers. The introduction of more efficient antiviral drugs are common cause drug-induced acute kidney injury (AKI). The true prevalence of antiviral drugs induced nephrotoxicity is hardly determined. It causes AKI by many mechanisms including acute tubular necrosis (ATN), allergic interstitial nephritis (AIN), and crystal nephropathy. ATN has been described with a few kinds of antiviral drugs such as cidofovir, adefovir and tenofovir with unique effects on transporter defects, apoptosis, and mitochondrial injury. AIN from atazanavir is a rapid onset of AKI and usually non-oliguric but dialytic therapy are needed because of severity. Additionally, crystal nephropathy from acyclovir, indinavir, and foscarnet can cause AKI due to intratubular obstruction. In this article, the mechanisms of antiviral drug-induced AKI were reviewed and strategies for preventing AKI were mentioned. 2020-01-27T07:52:19Z 2020-01-27T07:52:19Z 2019-01-01 Review Infectious Disorders - Drug Targets. Vol.19, No.4 (2019), 375-382 10.2174/1871526519666190617154137 18755852 18715265 2-s2.0-85077296781 https://repository.li.mahidol.ac.th/handle/123456789/50307 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077296781&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Wattana Leowattana Antiviral drugs and acute kidney injury (AKI) |
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© 2019 Bentham Science Publishers. The introduction of more efficient antiviral drugs are common cause drug-induced acute kidney injury (AKI). The true prevalence of antiviral drugs induced nephrotoxicity is hardly determined. It causes AKI by many mechanisms including acute tubular necrosis (ATN), allergic interstitial nephritis (AIN), and crystal nephropathy. ATN has been described with a few kinds of antiviral drugs such as cidofovir, adefovir and tenofovir with unique effects on transporter defects, apoptosis, and mitochondrial injury. AIN from atazanavir is a rapid onset of AKI and usually non-oliguric but dialytic therapy are needed because of severity. Additionally, crystal nephropathy from acyclovir, indinavir, and foscarnet can cause AKI due to intratubular obstruction. In this article, the mechanisms of antiviral drug-induced AKI were reviewed and strategies for preventing AKI were mentioned. |
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Mahidol University |
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Mahidol University Wattana Leowattana |
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Review |
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Wattana Leowattana |
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Wattana Leowattana |
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Antiviral drugs and acute kidney injury (AKI) |
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Antiviral drugs and acute kidney injury (AKI) |
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Antiviral drugs and acute kidney injury (AKI) |
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Antiviral drugs and acute kidney injury (AKI) |
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Antiviral drugs and acute kidney injury (AKI) |
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antiviral drugs and acute kidney injury (aki) |
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2020 |
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https://repository.li.mahidol.ac.th/handle/123456789/50307 |
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