Candidate microRNAs as Biomarkers in Malaria Infection: A Systematic Review

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. Malaria disease is a public health problem especially in tropical countries, 445.000 of malaria-related deaths have been reported in 2017. MicroRNAs (miRNAs) are small non-coding RNAs with 18-24 nucleoti...

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Main Authors: Gregorio Rangel, Nattawat Teerawattanapong, Supat Chamnanchanunt, Tsukuru Umemura, Anuwat Pinyachat, Surasak Wanram
Other Authors: Ubon Rajathanee University
Format: Article
Published: 2020
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/50342
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spelling th-mahidol.503422020-01-27T14:54:49Z Candidate microRNAs as Biomarkers in Malaria Infection: A Systematic Review Gregorio Rangel Nattawat Teerawattanapong Supat Chamnanchanunt Tsukuru Umemura Anuwat Pinyachat Surasak Wanram Ubon Rajathanee University International University of Health and Welfare Mahidol University Biochemistry, Genetics and Molecular Biology Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. Malaria disease is a public health problem especially in tropical countries, 445.000 of malaria-related deaths have been reported in 2017. MicroRNAs (miRNAs) are small non-coding RNAs with 18-24 nucleotides in length, which have been demonstrated to regulate gene expression of several biological processes. The dysregulation of host immune-related gene expressions during the transcriptional process by microRNA has been extensively reported in malaria parasite invasion of erythrocytes infection. The candidate's miRNAs would be used as potential biomarkers in the future and perspective. A systematic review on miRNAs as candidate clinical biomarkers in malaria infection has been established in this study. Electronic databases (Medline, EMBASE, CINAHL and Cochrane data bases) were screened and articles were included as per established selection criteria. We comprehensively searched to identify publications related to malaria and miRNA. PRISMA guidelines were followed, 262 articles were searched, duplicates and unconnected papers were excluded. Nineteen articles were included in the study. It was found that malaria parasite infected liver or tissue produce tissue-specific miRNAs and release to the blood stream. The association of miRNAs including miR-16, miR-155, miR-150, miR-451 and miR-223 with the dysregulations of immune-related genes expression such as PfEMP-1, IFN-γ, AGO- 1 AGO-2; IL4, CD80, CD86, CD36, ANG-1 and ANG-2 during early, severe and/or cerebral malaria infections indicate the potential use of those miRNAs as biomarkers for malaria infection. 2020-01-27T07:54:49Z 2020-01-27T07:54:49Z 2019-01-01 Article Current molecular medicine. Vol.20, No.1 (2019), 36-43 10.2174/1566524019666190820124827 18755666 2-s2.0-85077108555 https://repository.li.mahidol.ac.th/handle/123456789/50342 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85077108555&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Gregorio Rangel
Nattawat Teerawattanapong
Supat Chamnanchanunt
Tsukuru Umemura
Anuwat Pinyachat
Surasak Wanram
Candidate microRNAs as Biomarkers in Malaria Infection: A Systematic Review
description Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. Malaria disease is a public health problem especially in tropical countries, 445.000 of malaria-related deaths have been reported in 2017. MicroRNAs (miRNAs) are small non-coding RNAs with 18-24 nucleotides in length, which have been demonstrated to regulate gene expression of several biological processes. The dysregulation of host immune-related gene expressions during the transcriptional process by microRNA has been extensively reported in malaria parasite invasion of erythrocytes infection. The candidate's miRNAs would be used as potential biomarkers in the future and perspective. A systematic review on miRNAs as candidate clinical biomarkers in malaria infection has been established in this study. Electronic databases (Medline, EMBASE, CINAHL and Cochrane data bases) were screened and articles were included as per established selection criteria. We comprehensively searched to identify publications related to malaria and miRNA. PRISMA guidelines were followed, 262 articles were searched, duplicates and unconnected papers were excluded. Nineteen articles were included in the study. It was found that malaria parasite infected liver or tissue produce tissue-specific miRNAs and release to the blood stream. The association of miRNAs including miR-16, miR-155, miR-150, miR-451 and miR-223 with the dysregulations of immune-related genes expression such as PfEMP-1, IFN-γ, AGO- 1 AGO-2; IL4, CD80, CD86, CD36, ANG-1 and ANG-2 during early, severe and/or cerebral malaria infections indicate the potential use of those miRNAs as biomarkers for malaria infection.
author2 Ubon Rajathanee University
author_facet Ubon Rajathanee University
Gregorio Rangel
Nattawat Teerawattanapong
Supat Chamnanchanunt
Tsukuru Umemura
Anuwat Pinyachat
Surasak Wanram
format Article
author Gregorio Rangel
Nattawat Teerawattanapong
Supat Chamnanchanunt
Tsukuru Umemura
Anuwat Pinyachat
Surasak Wanram
author_sort Gregorio Rangel
title Candidate microRNAs as Biomarkers in Malaria Infection: A Systematic Review
title_short Candidate microRNAs as Biomarkers in Malaria Infection: A Systematic Review
title_full Candidate microRNAs as Biomarkers in Malaria Infection: A Systematic Review
title_fullStr Candidate microRNAs as Biomarkers in Malaria Infection: A Systematic Review
title_full_unstemmed Candidate microRNAs as Biomarkers in Malaria Infection: A Systematic Review
title_sort candidate micrornas as biomarkers in malaria infection: a systematic review
publishDate 2020
url https://repository.li.mahidol.ac.th/handle/123456789/50342
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