Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture

© 2019, Spandidos Publications. All rights reserved. Anterior cruciate ligament (ACL) rupture is one the most common musculoskeletal soft tissue injuries of the knee. Although the exact mechanisms of this injury remain uncertain, genetic variants have been considered to be an intrinsic risk factor a...

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Main Authors: Wanvisa Udomsinprasert, Pongsak Yuktanandana, Thanathep Tanpowpong, Somkiat Malila, Wiroj Jiamjarasrangsi, Sittisak Honsawek
Other Authors: Chulalongkorn University
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Published: 2020
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/50384
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spelling th-mahidol.503842020-01-27T14:57:54Z Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture Wanvisa Udomsinprasert Pongsak Yuktanandana Thanathep Tanpowpong Somkiat Malila Wiroj Jiamjarasrangsi Sittisak Honsawek Chulalongkorn University Mahidol University Biochemistry, Genetics and Molecular Biology © 2019, Spandidos Publications. All rights reserved. Anterior cruciate ligament (ACL) rupture is one the most common musculoskeletal soft tissue injuries of the knee. Although the exact mechanisms of this injury remain uncertain, genetic variants have been considered to be an intrinsic risk factor associated with ACL rupture. Therefore, the aim of the present study was to determine whether the adiponectin +276G/T polymorphism is associated with susceptibility to ACL rupture in a Thai population. Genotyping for rs1501299 was conducted in 98 participants with ACL rupture and 95 healthy controls by polymerase chain reaction-restriction fragment length polymorphism analysis. The results demonstrated that the GG genotype and G allele were significantly associated with an increased risk of ACL rupture [odds ratio (OR)=1.91, P=0.026; OR=1.89, P=0.004], whereas the TT genotype was significantly associated with a reduced risk of ACL rupture (OR=0.32, P=0.019). Furthermore, ACL injury patients with non-contact sports carrying the GG genotype and G allele exhibited a significantly higher risk of ACL rupture (OR=2.13, P=0.031; OR=1.84, P=0.029). In addition, overweight patients carrying the GG genotype and G allele had a significantly increased (8-fold) risk of ACL rupture (OR=8.00, P<0.001; OR=5.15, P<0.001), whereas overweight patients with the adiponectin +276G/T GT genotype had a significantly lower risk of ACL rupture (OR=0.13, P<0.001). Therefore, the adiponectin +276G/T polymorphism GG genotype and G allele were significantly associated with the risk of ACL rupture, particularly in overweight patients. These findings indicate that the adiponectin +276G/T polymorphism may play a role in the development of ACL rupture in the Thai population. 2020-01-27T07:57:54Z 2020-01-27T07:57:54Z 2019-01-01 Article Biomedical Reports. Vol.10, No.2 (2019), 133-139 10.3892/br.2018.1180 20499442 20499434 2-s2.0-85059679285 https://repository.li.mahidol.ac.th/handle/123456789/50384 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059679285&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Wanvisa Udomsinprasert
Pongsak Yuktanandana
Thanathep Tanpowpong
Somkiat Malila
Wiroj Jiamjarasrangsi
Sittisak Honsawek
Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture
description © 2019, Spandidos Publications. All rights reserved. Anterior cruciate ligament (ACL) rupture is one the most common musculoskeletal soft tissue injuries of the knee. Although the exact mechanisms of this injury remain uncertain, genetic variants have been considered to be an intrinsic risk factor associated with ACL rupture. Therefore, the aim of the present study was to determine whether the adiponectin +276G/T polymorphism is associated with susceptibility to ACL rupture in a Thai population. Genotyping for rs1501299 was conducted in 98 participants with ACL rupture and 95 healthy controls by polymerase chain reaction-restriction fragment length polymorphism analysis. The results demonstrated that the GG genotype and G allele were significantly associated with an increased risk of ACL rupture [odds ratio (OR)=1.91, P=0.026; OR=1.89, P=0.004], whereas the TT genotype was significantly associated with a reduced risk of ACL rupture (OR=0.32, P=0.019). Furthermore, ACL injury patients with non-contact sports carrying the GG genotype and G allele exhibited a significantly higher risk of ACL rupture (OR=2.13, P=0.031; OR=1.84, P=0.029). In addition, overweight patients carrying the GG genotype and G allele had a significantly increased (8-fold) risk of ACL rupture (OR=8.00, P<0.001; OR=5.15, P<0.001), whereas overweight patients with the adiponectin +276G/T GT genotype had a significantly lower risk of ACL rupture (OR=0.13, P<0.001). Therefore, the adiponectin +276G/T polymorphism GG genotype and G allele were significantly associated with the risk of ACL rupture, particularly in overweight patients. These findings indicate that the adiponectin +276G/T polymorphism may play a role in the development of ACL rupture in the Thai population.
author2 Chulalongkorn University
author_facet Chulalongkorn University
Wanvisa Udomsinprasert
Pongsak Yuktanandana
Thanathep Tanpowpong
Somkiat Malila
Wiroj Jiamjarasrangsi
Sittisak Honsawek
format Article
author Wanvisa Udomsinprasert
Pongsak Yuktanandana
Thanathep Tanpowpong
Somkiat Malila
Wiroj Jiamjarasrangsi
Sittisak Honsawek
author_sort Wanvisa Udomsinprasert
title Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture
title_short Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture
title_full Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture
title_fullStr Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture
title_full_unstemmed Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture
title_sort adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture
publishDate 2020
url https://repository.li.mahidol.ac.th/handle/123456789/50384
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