Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines

Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim An efficient and rapid synthetic approach for the synthesis of tetrazolo[1,5-a]quinolines has been developed employing the reaction of o-alkynylisocyanobenzenes with sodium azide. The present strategy involved nucleophilic addition of azide to...

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Main Authors: Onnicha Khaikate, Darunee Soorukram, Pawaret Leowanawat, Manat Pohmakotr, Vichai Reutrakul, Chutima Kuhakarn
Other Authors: Mahidol University
Format: Article
Published: 2020
Subjects:
Chemistry
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/50547
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spelling th-mahidol.505472020-01-27T15:09:57Z Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines Onnicha Khaikate Darunee Soorukram Pawaret Leowanawat Manat Pohmakotr Vichai Reutrakul Chutima Kuhakarn Mahidol University Chemistry © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim An efficient and rapid synthetic approach for the synthesis of tetrazolo[1,5-a]quinolines has been developed employing the reaction of o-alkynylisocyanobenzenes with sodium azide. The present strategy involved nucleophilic addition of azide to isocyanide followed by 6-endo cyclization. The reaction gives access to a collection of tetrazolo[1,5-a]quinolines with broad functional group in moderate to high yields under metal-, and base-free conditions. 2020-01-27T08:09:57Z 2020-01-27T08:09:57Z 2019-11-14 Article European Journal of Organic Chemistry. Vol.2019, No.42 (2019), 7050-7057 10.1002/ejoc.201901209 10990690 1434193X 2-s2.0-85074416371 https://repository.li.mahidol.ac.th/handle/123456789/50547 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074416371&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Chemistry
spellingShingle Chemistry
Onnicha Khaikate
Darunee Soorukram
Pawaret Leowanawat
Manat Pohmakotr
Vichai Reutrakul
Chutima Kuhakarn
Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines
description © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim An efficient and rapid synthetic approach for the synthesis of tetrazolo[1,5-a]quinolines has been developed employing the reaction of o-alkynylisocyanobenzenes with sodium azide. The present strategy involved nucleophilic addition of azide to isocyanide followed by 6-endo cyclization. The reaction gives access to a collection of tetrazolo[1,5-a]quinolines with broad functional group in moderate to high yields under metal-, and base-free conditions.
author2 Mahidol University
author_facet Mahidol University
Onnicha Khaikate
Darunee Soorukram
Pawaret Leowanawat
Manat Pohmakotr
Vichai Reutrakul
Chutima Kuhakarn
format Article
author Onnicha Khaikate
Darunee Soorukram
Pawaret Leowanawat
Manat Pohmakotr
Vichai Reutrakul
Chutima Kuhakarn
author_sort Onnicha Khaikate
title Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines
title_short Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines
title_full Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines
title_fullStr Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines
title_full_unstemmed Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines
title_sort azide-triggered bicyclization of o-alkynylisocyanobenzenes: synthesis of tetrazolo[1,5-a]quinolines
publishDate 2020
url https://repository.li.mahidol.ac.th/handle/123456789/50547
_version_ 1763493574732677120

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