Periodontitis as the risk factor of chronic kidney disease: Mediation analysis
© 2019 The Authors. Journal of Clinical Periodontology Published by John Wiley & Sons Ltd Aim: To determine sequences and magnitude of causality among periodontitis, diabetes and chronic kidney disease (CKD) by mediation analysis. Methods: Ten-year-data were retrieved from the Electric Generat...
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th-mahidol.507482020-01-27T15:28:45Z Periodontitis as the risk factor of chronic kidney disease: Mediation analysis Attawood Lertpimonchai Sasivimol Rattanasiri Suphot Tamsailom Chantrakorn Champaiboon Atiporn Ingsathit Chagriya Kitiyakara Anusorn Limpianunchai John Attia Piyamitr Sritara Ammarin Thakkinstian Hunter Medical Research Institute, Australia Chulalongkorn University Electricity Generating Authority of Thailand University of Newcastle, Faculty of Health and Medicine Faculty of Medicine, Ramathibodi Hospital, Mahidol University Dentistry © 2019 The Authors. Journal of Clinical Periodontology Published by John Wiley & Sons Ltd Aim: To determine sequences and magnitude of causality among periodontitis, diabetes and chronic kidney disease (CKD) by mediation analysis. Methods: Ten-year-data were retrieved from the Electric Generation Authority of Thailand (EGAT) study. A cohort of 2,635 subjects was identified with no CKD at baseline. The interested outcome was CKD incidence defined as glomerular filtration rate <60 ml/min/1.73 m2. The percentage of proximal sites with clinical attachment loss ≥5 mm was used to represent periodontitis. Mediation analysis with 1,000-replication bootstrapping was applied to two causal diagrams, diagram A (Periodontitis → Diabetes → CKD) and diagram B (Diabetes → Periodontitis → CKD). Results: The cumulative incidence of CKD was 10.3 cases per 100 persons during 10-year period. In diagram A, each increasing percentage of proximal sites with severe periodontitis increased the adjusted odds ratio of CKD 1.010 (95% CI: 1.005, 1.015) and 1.007 (95% CI: 1.004, 1.013), by direct and indirect effect through diabetes, respectively. In diagram B, diabetes increased the odds of CKD twofold, with 6.5% of this effect mediated via periodontitis. Conclusions: Periodontitis had significant direct effect, and indirect effect through diabetes, on the incidence of CKD. Awareness about systemic morbidities from periodontitis should be emphasized. 2020-01-27T08:28:45Z 2020-01-27T08:28:45Z 2019-01-01 Article Journal of Clinical Periodontology. Vol.46, No.6 (2019), 631-639 10.1111/jcpe.13114 1600051X 03036979 2-s2.0-85066420098 https://repository.li.mahidol.ac.th/handle/123456789/50748 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066420098&origin=inward |
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Dentistry |
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Dentistry Attawood Lertpimonchai Sasivimol Rattanasiri Suphot Tamsailom Chantrakorn Champaiboon Atiporn Ingsathit Chagriya Kitiyakara Anusorn Limpianunchai John Attia Piyamitr Sritara Ammarin Thakkinstian Periodontitis as the risk factor of chronic kidney disease: Mediation analysis |
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© 2019 The Authors. Journal of Clinical Periodontology Published by John Wiley & Sons Ltd Aim: To determine sequences and magnitude of causality among periodontitis, diabetes and chronic kidney disease (CKD) by mediation analysis. Methods: Ten-year-data were retrieved from the Electric Generation Authority of Thailand (EGAT) study. A cohort of 2,635 subjects was identified with no CKD at baseline. The interested outcome was CKD incidence defined as glomerular filtration rate <60 ml/min/1.73 m2. The percentage of proximal sites with clinical attachment loss ≥5 mm was used to represent periodontitis. Mediation analysis with 1,000-replication bootstrapping was applied to two causal diagrams, diagram A (Periodontitis → Diabetes → CKD) and diagram B (Diabetes → Periodontitis → CKD). Results: The cumulative incidence of CKD was 10.3 cases per 100 persons during 10-year period. In diagram A, each increasing percentage of proximal sites with severe periodontitis increased the adjusted odds ratio of CKD 1.010 (95% CI: 1.005, 1.015) and 1.007 (95% CI: 1.004, 1.013), by direct and indirect effect through diabetes, respectively. In diagram B, diabetes increased the odds of CKD twofold, with 6.5% of this effect mediated via periodontitis. Conclusions: Periodontitis had significant direct effect, and indirect effect through diabetes, on the incidence of CKD. Awareness about systemic morbidities from periodontitis should be emphasized. |
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Hunter Medical Research Institute, Australia |
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Hunter Medical Research Institute, Australia Attawood Lertpimonchai Sasivimol Rattanasiri Suphot Tamsailom Chantrakorn Champaiboon Atiporn Ingsathit Chagriya Kitiyakara Anusorn Limpianunchai John Attia Piyamitr Sritara Ammarin Thakkinstian |
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Article |
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Attawood Lertpimonchai Sasivimol Rattanasiri Suphot Tamsailom Chantrakorn Champaiboon Atiporn Ingsathit Chagriya Kitiyakara Anusorn Limpianunchai John Attia Piyamitr Sritara Ammarin Thakkinstian |
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Attawood Lertpimonchai |
title |
Periodontitis as the risk factor of chronic kidney disease: Mediation analysis |
title_short |
Periodontitis as the risk factor of chronic kidney disease: Mediation analysis |
title_full |
Periodontitis as the risk factor of chronic kidney disease: Mediation analysis |
title_fullStr |
Periodontitis as the risk factor of chronic kidney disease: Mediation analysis |
title_full_unstemmed |
Periodontitis as the risk factor of chronic kidney disease: Mediation analysis |
title_sort |
periodontitis as the risk factor of chronic kidney disease: mediation analysis |
publishDate |
2020 |
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https://repository.li.mahidol.ac.th/handle/123456789/50748 |
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1763496610483929088 |