The rise and fall of long-latency Plasmodium vivax
© 2018 The Author(s). Until World War II the only clinical phenotype of Plasmodium vivax generally recognised in medicine was one associated with either a long (8-9 months) incubation period or a similarly long interval between initial illness and the first relapse. Long-latency P. vivax strains...
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| Format: | Review |
| Published: |
2020
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| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/51081 |
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| Institution: | Mahidol University |
| Summary: | © 2018 The Author(s). Until World War II the only clinical phenotype of Plasmodium vivax generally recognised in medicine was one associated with either a long (8-9 months) incubation period or a similarly long interval between initial illness and the first relapse. Long-latency P. vivax strains' were the first in which relapse, drug resistance and pre-erythrocytic development were described. They were the infections in which primaquine radical cure dosing was developed. A long-latency strain' was the first to be fully sequenced. Although long-latency P. vivax is still present in some parts of Asia, North Africa and the Americas, in recent years it has been largely forgotten. |
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