Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2

© 2019 The Author(s). Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp. Using a risk-based approach, this review examines current practice, the evidence base and regulatory requirements regarding matters of biosafety and bi...

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Main Authors: Stuart D. Blacksell, Matthew T. Robinson, Paul N. Newton, Soiratchaneekorn Ruanchaimun, Jeanne Salje, Tri Wangrangsimakul, Matthew D. Wegner, Mohammad Yazid Abdad, Allan M. Bennett, Allen L. Richards, John Stenos, Nicholas P.J. Day
Other Authors: Public Health England
Format: Article
Published: 2020
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/51245
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spelling th-mahidol.512452020-01-27T16:16:53Z Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2 Stuart D. Blacksell Matthew T. Robinson Paul N. Newton Soiratchaneekorn Ruanchaimun Jeanne Salje Tri Wangrangsimakul Matthew D. Wegner Mohammad Yazid Abdad Allan M. Bennett Allen L. Richards John Stenos Nicholas P.J. Day Public Health England Churchill Hospital Geelong Hospital Armed Forces Research Institute of Medical Sciences, Thailand Mahidol University Uniformed Services University of the Health Sciences National Centre for Infectious Diseases Mahosot Hospital Medicine © 2019 The Author(s). Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp. Using a risk-based approach, this review examines current practice, the evidence base and regulatory requirements regarding matters of biosafety and biosecurity, and presents the case for reclassification from Risk Group 3 to Risk Group 2 along with recommendations for safe working practices of risk-based activities during the manipulation of Orientia spp. in the laboratory. We recommend to reclassify Orientia spp. to Risk Group 2 based on the classification for RG2 pathogens as being moderate individual risk, low community risk. We recommend that low risk activities, can be performed within a biological safety cabinet located in a Biosafety Level (BSL) 2 core laboratory using standard personal protective equipment. But when the risk assessment indicates, such as high concentration and volume, or aerosol generation, then a higher biocontainment level is warranted. For, the majority of animal activities involving Orientia spp., Animal BSL 2 (ABSL2) is recommended however where high risk activities are performed including necropsies, Animal BSL (ABSL3) is recommended. 2020-01-27T09:16:53Z 2020-01-27T09:16:53Z 2019-12-10 Article BMC Infectious Diseases. Vol.19, No.1 (2019) 10.1186/s12879-019-4653-4 14712334 2-s2.0-85076339022 https://repository.li.mahidol.ac.th/handle/123456789/51245 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076339022&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Stuart D. Blacksell
Matthew T. Robinson
Paul N. Newton
Soiratchaneekorn Ruanchaimun
Jeanne Salje
Tri Wangrangsimakul
Matthew D. Wegner
Mohammad Yazid Abdad
Allan M. Bennett
Allen L. Richards
John Stenos
Nicholas P.J. Day
Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
description © 2019 The Author(s). Scrub typhus is an important arthropod-borne disease causing significant acute febrile illness by infection with Orientia spp. Using a risk-based approach, this review examines current practice, the evidence base and regulatory requirements regarding matters of biosafety and biosecurity, and presents the case for reclassification from Risk Group 3 to Risk Group 2 along with recommendations for safe working practices of risk-based activities during the manipulation of Orientia spp. in the laboratory. We recommend to reclassify Orientia spp. to Risk Group 2 based on the classification for RG2 pathogens as being moderate individual risk, low community risk. We recommend that low risk activities, can be performed within a biological safety cabinet located in a Biosafety Level (BSL) 2 core laboratory using standard personal protective equipment. But when the risk assessment indicates, such as high concentration and volume, or aerosol generation, then a higher biocontainment level is warranted. For, the majority of animal activities involving Orientia spp., Animal BSL 2 (ABSL2) is recommended however where high risk activities are performed including necropsies, Animal BSL (ABSL3) is recommended.
author2 Public Health England
author_facet Public Health England
Stuart D. Blacksell
Matthew T. Robinson
Paul N. Newton
Soiratchaneekorn Ruanchaimun
Jeanne Salje
Tri Wangrangsimakul
Matthew D. Wegner
Mohammad Yazid Abdad
Allan M. Bennett
Allen L. Richards
John Stenos
Nicholas P.J. Day
format Article
author Stuart D. Blacksell
Matthew T. Robinson
Paul N. Newton
Soiratchaneekorn Ruanchaimun
Jeanne Salje
Tri Wangrangsimakul
Matthew D. Wegner
Mohammad Yazid Abdad
Allan M. Bennett
Allen L. Richards
John Stenos
Nicholas P.J. Day
author_sort Stuart D. Blacksell
title Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
title_short Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
title_full Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
title_fullStr Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
title_full_unstemmed Biosafety and biosecurity requirements for Orientia spp. diagnosis and research: Recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
title_sort biosafety and biosecurity requirements for orientia spp. diagnosis and research: recommendations for risk-based biocontainment, work practices and the case for reclassification to risk group 2
publishDate 2020
url https://repository.li.mahidol.ac.th/handle/123456789/51245
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