Factors that predict recurrent spontaneous bacterial peritonitis in cirrhotic patients
© 2019 John Wiley & Sons Ltd Background: The recurrence rate of spontaneous bacterial peritonitis (SBP) is increasing in cirrhotic patients. Antibiotic prophylaxis should be prescribed in all cirrhotic patients after the first episode of SBP. However, antibiotics promote the development of ant...
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th-mahidol.520042020-01-27T17:16:09Z Factors that predict recurrent spontaneous bacterial peritonitis in cirrhotic patients Panotpol Termsinsuk Chonticha Auesomwang Faculty of Medicine, Siriraj Hospital, Mahidol University Medicine © 2019 John Wiley & Sons Ltd Background: The recurrence rate of spontaneous bacterial peritonitis (SBP) is increasing in cirrhotic patients. Antibiotic prophylaxis should be prescribed in all cirrhotic patients after the first episode of SBP. However, antibiotics promote the development of antibiotic-resistant bacteria. Objective: To identify the factors that predict the recurrence of SBP after the first episode in cirrhotic patients to optimise the stratification for secondary antibiotic prophylaxis. Methods: This retrospective study included 145 cirrhotic patients who had their first SBP episode during 2011-2015. The 86 patients who survived were divided into either the SBP recurrence or non-recurrence group according to patient SBP outcome during the 2-year follow-up. Demographical, clinical and laboratory parameters were recorded at SBP diagnosis and before hospital discharge. SBP recurrence rate, recurrence-free survival and in-hospital mortality were also analysed. Results: The recurrence rate of SBP after the first episode was 69.8% (60/86), and the median recurrence-free survival time was 142 days. The in-hospital mortality rate was 40.7% (59/145). The significant predictive factors for recurrence of SBP were serum potassium ≥4 mEq/L (HR: 1.89; P =.028), serum albumin ≤2 g/dL (HR: 2.5; P =.003) at diagnosis of SBP and platelet count before discharge ≤100 000/microliter (HR: 1.93; P =.029). Conclusion: SBP frequently recurs in cirrhotic patients. Serum potassium ≥4 mEq/L, serum albumin ≤2g/dL at SBP diagnosis and platelet count ≤100 000/microliter before discharge were identified as factors that may predict the recurrence of SBP after the first episode. 2020-01-27T10:16:09Z 2020-01-27T10:16:09Z 2019-01-01 Article International Journal of Clinical Practice. (2019) 10.1111/ijcp.13457 17421241 13685031 2-s2.0-85076722149 https://repository.li.mahidol.ac.th/handle/123456789/52004 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076722149&origin=inward |
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Medicine Panotpol Termsinsuk Chonticha Auesomwang Factors that predict recurrent spontaneous bacterial peritonitis in cirrhotic patients |
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© 2019 John Wiley & Sons Ltd Background: The recurrence rate of spontaneous bacterial peritonitis (SBP) is increasing in cirrhotic patients. Antibiotic prophylaxis should be prescribed in all cirrhotic patients after the first episode of SBP. However, antibiotics promote the development of antibiotic-resistant bacteria. Objective: To identify the factors that predict the recurrence of SBP after the first episode in cirrhotic patients to optimise the stratification for secondary antibiotic prophylaxis. Methods: This retrospective study included 145 cirrhotic patients who had their first SBP episode during 2011-2015. The 86 patients who survived were divided into either the SBP recurrence or non-recurrence group according to patient SBP outcome during the 2-year follow-up. Demographical, clinical and laboratory parameters were recorded at SBP diagnosis and before hospital discharge. SBP recurrence rate, recurrence-free survival and in-hospital mortality were also analysed. Results: The recurrence rate of SBP after the first episode was 69.8% (60/86), and the median recurrence-free survival time was 142 days. The in-hospital mortality rate was 40.7% (59/145). The significant predictive factors for recurrence of SBP were serum potassium ≥4 mEq/L (HR: 1.89; P =.028), serum albumin ≤2 g/dL (HR: 2.5; P =.003) at diagnosis of SBP and platelet count before discharge ≤100 000/microliter (HR: 1.93; P =.029). Conclusion: SBP frequently recurs in cirrhotic patients. Serum potassium ≥4 mEq/L, serum albumin ≤2g/dL at SBP diagnosis and platelet count ≤100 000/microliter before discharge were identified as factors that may predict the recurrence of SBP after the first episode. |
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Faculty of Medicine, Siriraj Hospital, Mahidol University |
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Faculty of Medicine, Siriraj Hospital, Mahidol University Panotpol Termsinsuk Chonticha Auesomwang |
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Article |
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Panotpol Termsinsuk Chonticha Auesomwang |
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Panotpol Termsinsuk |
title |
Factors that predict recurrent spontaneous bacterial peritonitis in cirrhotic patients |
title_short |
Factors that predict recurrent spontaneous bacterial peritonitis in cirrhotic patients |
title_full |
Factors that predict recurrent spontaneous bacterial peritonitis in cirrhotic patients |
title_fullStr |
Factors that predict recurrent spontaneous bacterial peritonitis in cirrhotic patients |
title_full_unstemmed |
Factors that predict recurrent spontaneous bacterial peritonitis in cirrhotic patients |
title_sort |
factors that predict recurrent spontaneous bacterial peritonitis in cirrhotic patients |
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2020 |
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https://repository.li.mahidol.ac.th/handle/123456789/52004 |
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1763491447153098752 |